Diffusion MRI monitoring of microstructure in the irradiated rat brain
Event details
| Date | 14.12.2016 |
| Hour | 14:00 › 15:00 |
| Speaker | Julie Constanzo |
| Location | |
| Category | Conferences - Seminars |
Metastatic brain tumors, which are typically well circumscribed, often provide an ideal target for stereotactic radiosurgery (SRS). The goal of SRS is to limit tumor growth while minimizing the risk of long-term neurotoxic or cognitive side effects. However, implementing SRS can be difficult given that during treatment, surrounding healthy tissue will inevitably receive a significant dose of radiation. This may lead to clinical complications, such as delayed formation of edema in the irradiated volume, and in some cases, to necrosis. Despite substantial improvements in diffusion MRI (dMRI) metrics, including diffusion tensor imaging (DTI) and high angular resolution diffusion imaging (HARDI), analysis of biological and microstructural properties remains challenging. HARDI in particular has the potential of elucidating abnormal connectivity in axonal path disorder but also in grey matter where the complexity of fiber bundles is poorly understood.
We developed a radiation necrosis model with a lesion located mainly into the white matter and the primary motor cortex (M1) of the right hemisphere of the rat brain. In this model we investigated whether dMRI indices correlated with histopathology and behavioral changes.
Bio: Since December 2015, Julie Constanzo hold a research scientist position (3 years) in the department of Hadrontherapy, Radiobiology and Molecular Imaging (DHRIM) at Institut Pluridisciplinaire Hubert Curien, CNRS, University of Strasbourg, France. She obtained her PhD degree at University Claude Bernard, Lyon 1 in 2013, where she conducted dosimetry, irradiation and radiobiological studies with protons and carbon ions at cellular level. Then, she completed her postdoctoral fellow in the department of Nuclear Medicine and Radiobiology at University of Sherbrooke, Canada in 2014, performing preclinical studies. Julie Constanzo acquired both physics and biology skills as dosimetry, irradiation, animal model, imaging application, histopathology and behavioral tests. Using a translational approach, the aim of its work is to better understand radiation-induced adverse effects in the brain to improve treatment planning, patient management, and to develop new therapeutic strategies in a close collaboration with radiation oncologists.
We developed a radiation necrosis model with a lesion located mainly into the white matter and the primary motor cortex (M1) of the right hemisphere of the rat brain. In this model we investigated whether dMRI indices correlated with histopathology and behavioral changes.
Bio: Since December 2015, Julie Constanzo hold a research scientist position (3 years) in the department of Hadrontherapy, Radiobiology and Molecular Imaging (DHRIM) at Institut Pluridisciplinaire Hubert Curien, CNRS, University of Strasbourg, France. She obtained her PhD degree at University Claude Bernard, Lyon 1 in 2013, where she conducted dosimetry, irradiation and radiobiological studies with protons and carbon ions at cellular level. Then, she completed her postdoctoral fellow in the department of Nuclear Medicine and Radiobiology at University of Sherbrooke, Canada in 2014, performing preclinical studies. Julie Constanzo acquired both physics and biology skills as dosimetry, irradiation, animal model, imaging application, histopathology and behavioral tests. Using a translational approach, the aim of its work is to better understand radiation-induced adverse effects in the brain to improve treatment planning, patient management, and to develop new therapeutic strategies in a close collaboration with radiation oncologists.
Practical information
- Informed public
- Free
- This event is internal
Contact
- Maxime Descoteaux