Enabling Single-Molecule Measurements with Microfluidics and Optical Microresonators: Disordered Proteins and Semiconducting Polymers
Event details
| Date | 04.05.2015 |
| Hour | 14:00 |
| Speaker | Prof. Randall H. Goldsmith, University of Wisconsin, Madison, WI (USA) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
Abstract:
Single-Molecule measurements offer a wealth of detail about chemical diversity and unsynchronized dynamics, but only if the system under study is conducive to known methods of single-molecule fluoresence microscopy. I will present two cases where new measurement technology enables new observations on individual molecules. In the first case, a microfluidic trap that cancels Brownian motion will be used to explore the solution-phase conformation of an intrinsically disordered protein, Tau, central to the etiology of Alzheimer’s Disease. In the second case, a method to enable study of non-fluorescent molecules will be described using ultrahigh quality-factor optical microresonators as platforms for spectroscopy. This method will be applied to study the electronic structure of doped conjugated polymers.
Bio:
B.A. 2002, Cornell University
Ph.D. 2007, Northwestern University (supervisor: W.E. Moerner)
Postdoctoral Researcher at Stanford University
Abstract:
Single-Molecule measurements offer a wealth of detail about chemical diversity and unsynchronized dynamics, but only if the system under study is conducive to known methods of single-molecule fluoresence microscopy. I will present two cases where new measurement technology enables new observations on individual molecules. In the first case, a microfluidic trap that cancels Brownian motion will be used to explore the solution-phase conformation of an intrinsically disordered protein, Tau, central to the etiology of Alzheimer’s Disease. In the second case, a method to enable study of non-fluorescent molecules will be described using ultrahigh quality-factor optical microresonators as platforms for spectroscopy. This method will be applied to study the electronic structure of doped conjugated polymers.
Bio:
B.A. 2002, Cornell University
Ph.D. 2007, Northwestern University (supervisor: W.E. Moerner)
Postdoctoral Researcher at Stanford University
Practical information
- Informed public
- Free