Engineering organoids for the testing of rare bone marrow stromal cell populations
The bone marrow (BM) is an intricate and tightly regulated organ, home to hematopoietic stem and progenitor cells (HSPCs) as well as bone marrow stromal cells (BMSCs) that sustain the body’s hematopoietic system and drive connective tissue regeneration. Recent findings indicate that BMSCs are a heterogeneous, not fully defined cell population comprising, among others, minor fractions of skeletal stem cells. To decipher the function of low abundant BMSC populations, there is a great need to develop tailorable in vitro and in vivo models. I will present the engineering of bone and bone marrow organoid models using a modular designed poly(ethylene glycol) PEG-based hydrogel. I will show how we make use of these models to characterize human BMSCs in vivo. Finally, I will give an insight into our ongoing research activities on the refinement of our current models towards their use in a multiplexing format for the testing and manipulation of rare bone marrow stromal cell populations.
-> Hosting unit: Deplancke lab
-> SV 1717: masks & COVID pass requested
-> Zoom passcode: 1372
-> Hosting unit: Deplancke lab
-> SV 1717: masks & COVID pass requested
-> Zoom passcode: 1372
Practical information
- Informed public
- Free
- This event is internal