“Genetic and non-genetic routes of tumor evolution"
Event details
| Date | 17.06.2021 |
| Hour | 12:15 › 13:30 |
| Speaker |
Giovanni Ciriello, Associate Professor since 1 August 2019 - Department of Computational Biology A specialist in computational biology and cancer genomics, Giovanni Ciriello explores how to develop a systemic understanding of genetic and epigenetic modifications in the field of oncology for therapeutic purposes. He has been appointed Associate Professor in the Department of Computational Biology at UNIL as of 1 August 2019. |
| Location | Online |
| Category | Conferences - Seminars |
A Lola and John Grace Distinguished Lecture in Cancer Research
Giovanni Ciriello was born in 1980 and is an Italian national. He studied computational science and engineering at the University of Padua in Italy (2005). He then completed his PhD under the supervision of Prof. Concettina Guerra, first at the University of Padua and then at the College of Computing at the Georgia Institute of Technology in Atlanta, USA (2009). There he started to work in the field of bioinformatics: he developed algorithms to identify recurrent motifs within ribosomal RNAs and interaction sites between RNAs and proteins, and between proteins themselves.
In 2010, Giovanni Ciriello joined the laboratory of Prof. Chris Sander at Memorial Sloan Kettering Cancer Center in New York, where he is developing new computational methods for large-scale analysis of oncogenomic data. In particular, he is exploring mutually exclusive (i.e. never coexisting within the same tumour type) patterns of recurrent oncogenic mutations. He is also studying how to use these recurrent alterations to identify tissue-independent tumour subpopulations that could benefit from the same treatment. In addition, Giovanni Ciriello has contributed to several projects conducted within the framework of The Cancer Genome Atlas (TCGA) research network, of which he is a member.
In April 2015, Giovanni Ciriello was appointed assistant professor on conditional pre-tenure in the Department of Medical Genetics at UNIL (renamed Department of Computational Biology in 2016). He is appointed associate professor as of 1 August 2019. Since his arrival in Lausanne in 2015, Giovanni Ciriello has been pursuing his research in the field of oncogenetics and oncogenomics. By systematically analysing specific molecular signatures of tumour subclasses, he predicts the consequences of these signatures at the functional and cellular level, studies their interdependencies and explores their therapeutic implications, such as their response to treatments.
Within this framework, the scientist's first line of research is to design new computational approaches to integrate and analyse the different types of molecular modifications and understand how they cooperate in the tumour. He has also developed methods for the systematic and comprehensive analysis of large amounts of genomic data in order to explore the origin of cancers and their progression. Finally, Giovanni Ciriello has also developed a translational approach by collaborating with laboratories specialised in genetics and oncology to test and validate his hypotheses. The study of interdependencies between mutations has opened the way to new approaches to predict the best therapy based on the combination of alterations within a tumour.
Giovanni Ciriello was born in 1980 and is an Italian national. He studied computational science and engineering at the University of Padua in Italy (2005). He then completed his PhD under the supervision of Prof. Concettina Guerra, first at the University of Padua and then at the College of Computing at the Georgia Institute of Technology in Atlanta, USA (2009). There he started to work in the field of bioinformatics: he developed algorithms to identify recurrent motifs within ribosomal RNAs and interaction sites between RNAs and proteins, and between proteins themselves.
In 2010, Giovanni Ciriello joined the laboratory of Prof. Chris Sander at Memorial Sloan Kettering Cancer Center in New York, where he is developing new computational methods for large-scale analysis of oncogenomic data. In particular, he is exploring mutually exclusive (i.e. never coexisting within the same tumour type) patterns of recurrent oncogenic mutations. He is also studying how to use these recurrent alterations to identify tissue-independent tumour subpopulations that could benefit from the same treatment. In addition, Giovanni Ciriello has contributed to several projects conducted within the framework of The Cancer Genome Atlas (TCGA) research network, of which he is a member.
In April 2015, Giovanni Ciriello was appointed assistant professor on conditional pre-tenure in the Department of Medical Genetics at UNIL (renamed Department of Computational Biology in 2016). He is appointed associate professor as of 1 August 2019. Since his arrival in Lausanne in 2015, Giovanni Ciriello has been pursuing his research in the field of oncogenetics and oncogenomics. By systematically analysing specific molecular signatures of tumour subclasses, he predicts the consequences of these signatures at the functional and cellular level, studies their interdependencies and explores their therapeutic implications, such as their response to treatments.
Within this framework, the scientist's first line of research is to design new computational approaches to integrate and analyse the different types of molecular modifications and understand how they cooperate in the tumour. He has also developed methods for the systematic and comprehensive analysis of large amounts of genomic data in order to explore the origin of cancers and their progression. Finally, Giovanni Ciriello has also developed a translational approach by collaborating with laboratories specialised in genetics and oncology to test and validate his hypotheses. The study of interdependencies between mutations has opened the way to new approaches to predict the best therapy based on the combination of alterations within a tumour.
Practical information
- Informed public
- Free
- This event is internal
Organizer
- Prof. Freddy RADTKE
Contact
- Lisa Smith, ISREC Administrative Assistant (please contact me for the Zoom passcode for this seminar) There will also be a limited number of seats available in conference room SV 1717 to ease back the return of in person seminars.