Genetic approaches to mouse brain circuit mapping and cell type characterization
Event details
| Date | 07.10.2013 |
| Hour | 13:30 › 14:30 |
| Speaker | Hongkui Zeng, Allen Institute for Brain Science, Seattle, WA, USA |
| Location | |
| Category | Conferences - Seminars |
The brain circuit is an intricately interconnected network of a vast number of neurons with diverse molecular, anatomical and physiological properties. We have been working on developing technologies that will enable the identification, labeling, monitoring and manipulation of different neuronal cell types, and on using a combined molecular, genetic and physiological approach to unravel the diversity and connectivity of the neuronal cell types that compose of neural circuits. In the Transgenic Technology program, we build transgenic mouse lines that target sensors and effectors to specific types of neurons. In the Mouse Cell Types program, we use the mouse visual system as a model to systematically characterize the transcriptomic, morphological, and electrophysiological properties of different kinds of neurons, towards a systematic taxonomy of cell types for this circuit. Finally, we wish to gain a comprehensive and detailed understanding of how different types of neurons are connected to each other. The Mouse Brain Connectivity Atlas project represents the first of such large-scale efforts, in which axonal projections from different regions and different cell types within these regions are systematically mapped throughout the brain to generate a 3D whole-brain projectome.
Practical information
- General public
- Free
Organizer
- Sean Hill, BBP http://people.epfl.ch/sean.hill?lang=en