Genetic Biosensors and Chemogenetic Tools: Unlocking Redox Biology through Multiparametric Imaging
Event details
| Date | 15.12.2023 |
| Hour | 10:00 › 11:00 |
| Speaker | Prof. Emrah Eroğlu, Principal Investigator and Deputy Director, Research Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University (TR) |
| Location | Online |
| Category | Conferences - Seminars |
| Event Language | English |
BIOENGINEERING SEMINAR
Abstract:
This lecture presents our latest advancements in developing innovative strategies for multiparametric imaging of cellular redox signaling events. By harnessing genetically encoded fluorescent protein-based biosensors for Calcium and reactive molecules such as ROS and RNS, the field of redox biology has witnessed a transformative shift. These powerful tools enable the visualization of biological processes with exceptional spatial and temporal resolution, both in vitro and in vivo. We have expanded the repertoire of genetically encodable tools and introduced novel chemogenetic enzymes that can precisely manipulate the cellular and tissue-level redox tone. The integration of diverse genetic biosensors and chemogenetic devices has paved the way for groundbreaking investigations into ROS and RNS signaling pathways through multiparametric live-cell imaging with unparalleled precision. Nonetheless, there remains untapped potential in these approaches that redox biologists have yet to explore fully. This lecture will delve into recent progress and future prospects of these toolkits, highlighting their capacity to bridge existing knowledge gaps in our understanding of redox biology.
Bio:
Zoom link for attending remotely: https://epfl.zoom.us/j/67346839751
Abstract:
This lecture presents our latest advancements in developing innovative strategies for multiparametric imaging of cellular redox signaling events. By harnessing genetically encoded fluorescent protein-based biosensors for Calcium and reactive molecules such as ROS and RNS, the field of redox biology has witnessed a transformative shift. These powerful tools enable the visualization of biological processes with exceptional spatial and temporal resolution, both in vitro and in vivo. We have expanded the repertoire of genetically encodable tools and introduced novel chemogenetic enzymes that can precisely manipulate the cellular and tissue-level redox tone. The integration of diverse genetic biosensors and chemogenetic devices has paved the way for groundbreaking investigations into ROS and RNS signaling pathways through multiparametric live-cell imaging with unparalleled precision. Nonetheless, there remains untapped potential in these approaches that redox biologists have yet to explore fully. This lecture will delve into recent progress and future prospects of these toolkits, highlighting their capacity to bridge existing knowledge gaps in our understanding of redox biology.
Bio:
2022-2023 Deputy Director of SABITA in Istanbul Medipol University
2019-2022 Faculty Member at Sabancı University
2017-2019 Postdoctoral Fellow (Harvard Medical School)
2016 -2017 Postdoctoral Fellow (MedUni Graz)
2015 -2016 PhD Student Molecular Medicine (Molecular Medicine Program, MedUni Graz)
2013-present Medicine (Meduni Graz)
2012 -2015 Master’s degree in Biotechnology and Bioanalytics (Vienna University of Technology)
2012 -2012 Exam for nationally certified pharmaceutical representative (Ministry of Health, Austria).
2008 -2012 Bachelor’s degree in Biology and Molecular biology (Vienna University)
2007 -2008 University entrance exam (Vienna University)
2019-2022 Faculty Member at Sabancı University
2017-2019 Postdoctoral Fellow (Harvard Medical School)
2016 -2017 Postdoctoral Fellow (MedUni Graz)
2015 -2016 PhD Student Molecular Medicine (Molecular Medicine Program, MedUni Graz)
2013-present Medicine (Meduni Graz)
2012 -2015 Master’s degree in Biotechnology and Bioanalytics (Vienna University of Technology)
2012 -2012 Exam for nationally certified pharmaceutical representative (Ministry of Health, Austria).
2008 -2012 Bachelor’s degree in Biology and Molecular biology (Vienna University)
2007 -2008 University entrance exam (Vienna University)
Zoom link for attending remotely: https://epfl.zoom.us/j/67346839751
Practical information
- Informed public
- Free
Organizer
- Prof. Hilal Lashuel, EPFL