Harnessing massive peptide libraries to explore the inhibition of epigenetic drug targets


Event details

Date 30.06.2020
Hour 16:0017:45
Speaker Prof. Louise Walport
Category Conferences - Seminars

Epigenetic regulators finely tune gene regulation in a healthy cell, but their misregulation frequently contributes to disease. In many cases, however, achieving selective inhibition has been challenging, due to the presence of a multiple, closely-related isoforms. Cyclic peptides are an emerging class of natural product-like drugs with diverse structures that can easily be adapted to potently and selectively target any protein of interest. This talk will discuss the use of the RaPID system, a trillion member cyclic peptide discovery platform, to develop potent and selective modulators of two epigenetic drug targets: the rheumatoid arthritis target, PADI4, and the cancer targets, the BET bromodomains.

Practical information

  • General public
  • Free


  • Prof. Beat Fierz        


  • Marie Munoz