How Do Enzymes Really Work and How Do They Not Work: What Has Been Learnt From Computer Simulation Studies?
Event details
| Date | 19.05.2009 |
| Hour | 11:00 |
| Speaker | Prof. Arieh Warshel, University of Southern California |
| Location | |
| Category | Conferences - Seminars |
Biological systems were optimized by evolution to reach a maximum overall efficiency. However, the available structural, spectroscopical, and biochemical information does not allow one to determine what the most important catalytic contributions are. Apparently, in many cases it is crucial to use computer simulation approaches in order to find out the actual contribution from the different proposed catalytic factors (1-3). The talk will start with a clear definition of catalysis, emphasizing the crucial need for a reference state. After a brief description of reliable approaches for the simulation of enzymatic reactions, we will point out that all consistent simulation studies have concluded that enzymes work by using their preorganized polar environment to stabilize the transition state of the reacting substrates. [...]
Practical information
- General public
- Free
Contact
- Prof. Clemence Corminboeuf