Making sense of muscle stem cell heterogeneities
Event details
| Date | 02.05.2014 |
| Hour | 11:00 › 12:00 |
| Speaker | Dr. Shahragim Tajbakhsh |
| Location | |
| Category | Conferences - Seminars |
The regulatory cell state of muscle stem cells fluctuates during perinatal growth, after entering quiescence, and following muscle injury when amplification of the stem cell pool results in the production of myoblasts and future self-renewing cells. We have noted a heterogeneity in the muscle stem cell pool during quiescence and proliferation. A major regulator of cellular quiescence in this tissue is Notch signaling, which is lost rapidly following cell cycle reentry, then restored during self-renewal. We and others have reported that Notch signaling could mediate the stability of the niche by regulating extracellular matrix molecules. These observations will be discussed in the context of regulation and maintenance of the stem cell state
Practical information
- General public
- Free
Contact
- Prof. Freddy Radtke