Mechanics of Blastocyst Morphogenesis
Event details
| Date | 16.08.2017 |
| Hour | 15:00 › 16:00 |
| Speaker | Jean-Léon Maître, Ph.D., Institut Curie, Paris (F) |
| Location | |
| Category | Conferences - Seminars |
BIOENGINEERING SEMINAR
Abstract:
During pre-implantation development, the mammalian embryo forms the blastocyst, which will implant into the uterus. The architecture of the blastocyst is essential to the specification of the first mammalian lineages and to the implantation of the embryo. Consisting of an epithelium enveloping a fluid-filled cavity and the inner cell mass, the blastocyst is sculpted by a succession of morphogenetic events. These deformations result from the changes in the forces and mechanical properties of the tissue composing the embryo.
Using microaspiration, live-imaging, genetics and theoretical modelling, we study the biophysical and cellular changes leading to the formation of the blastocyst. In particular, we uncover the crucial role of acto-myosin contractility, which generates periodic waves of contractions, compacts the embryo, controls the position of cells within the embryo and influences fate specification.
Bio:
2016 - current
Group leader at Institut Curie (Paris, F) in the Genetics and Developmental Biology unit CNRS UMR3215, INSERM U934
2013 - 2016
Postdoc fellow in the Hiiragi Lab at the European Molecular Biology Laboratory (Heidelberg, D)
2007 - 2012
PhD student in the Heisenberg Lab at the Max Planck Institute for Cell Biology and Genetics (Dresden, D) and the Institute of Science and Technology Austria (Klosterneuburg, AT)
2006 - 2007
Master student in the Génot Lab at the Institut Européen de Chimie et Biologie (Pessac, F)
2006
Master student in the Martinez-Arias Lab at the University of Cambridge (UK), in the Dept. of Genetics
Abstract:
During pre-implantation development, the mammalian embryo forms the blastocyst, which will implant into the uterus. The architecture of the blastocyst is essential to the specification of the first mammalian lineages and to the implantation of the embryo. Consisting of an epithelium enveloping a fluid-filled cavity and the inner cell mass, the blastocyst is sculpted by a succession of morphogenetic events. These deformations result from the changes in the forces and mechanical properties of the tissue composing the embryo.
Using microaspiration, live-imaging, genetics and theoretical modelling, we study the biophysical and cellular changes leading to the formation of the blastocyst. In particular, we uncover the crucial role of acto-myosin contractility, which generates periodic waves of contractions, compacts the embryo, controls the position of cells within the embryo and influences fate specification.
Bio:
2016 - current
Group leader at Institut Curie (Paris, F) in the Genetics and Developmental Biology unit CNRS UMR3215, INSERM U934
2013 - 2016
Postdoc fellow in the Hiiragi Lab at the European Molecular Biology Laboratory (Heidelberg, D)
2007 - 2012
PhD student in the Heisenberg Lab at the Max Planck Institute for Cell Biology and Genetics (Dresden, D) and the Institute of Science and Technology Austria (Klosterneuburg, AT)
2006 - 2007
Master student in the Génot Lab at the Institut Européen de Chimie et Biologie (Pessac, F)
2006
Master student in the Martinez-Arias Lab at the University of Cambridge (UK), in the Dept. of Genetics
Practical information
- Informed public
- Free
Organizer
Contact
- Institute of Bioengineering (IBI, Dietrich REINHARD)