MechE Colloquium: Folds, Rolls and Swirls of cells: Reconstituting Morphogenesis in Vitro


Event details

Date 15.11.2022
Hour 12:0013:00
Speaker Prof. Aurélien Roux, School of Chemistry and Biochemistry, University of Geneva (UNIGE)
Location Online
Category Conferences - Seminars
Event Language English
Abstract: In order to understand basic mechanisms of tissue morphogenesis, my lab developed in vitro assays to study the self-morphogenesis of cell assemblies under various constraints. In particular, we show that proliferation pressure rising inside an epithelium growing under confinement is sufficient for it to buckle. When cell layers are rolled, they transiently swell up to 50% of their initial volume. Also, myoblasts spontaneously organise into spirals when confined onto a surface, and proliferate into a vortex that further grows as a tornado. I will discuss how these in vitro process could be relevant for the understanding of embryonic development.

Biography: Aurélien Roux studied biology at the Ecole Normale Supérieure de Lyon, France (1997-1999), with a minor in Physics. He did a Master of Physics, University Denis Diderot, Paris (1999-2000). As a Ph.D student with Patricia Bassereau and Bruno Goud (Curie Institute, Paris, 2000-2004), he studied how lipids can be sorted by membrane curvature. He then did his post-doctoral work with Pietro de Camilli (2004-2007, Yale, USA), reconstituting in vitro dynamin mediated membrane fission, which he continued as a CNRS staff scientist (Institut Curie, Paris, 2007-2010). Appointed assistant professor of Biochemistry, Geneva (2010-2015), he expanded his work towards ESCRT-III, the most ancient and ubiquitous fission machinery in the cell. In 2016, he was tenured to associate professor at Unige, and then Full professor in 2020. During this period, he developed assays to reconstitute spontaneous morphogenesis of cellular assemblies in vitro.

Practical information

  • General public
  • Free



MechE Colloquium: Folds Rolls and Swirls of cells: Reconstituting Morphogenesis in Vitro