Metal-catalyzed activation of inert molecular bonds
Event details
| Date | 24.10.2012 |
| Hour | 17:15 › 18:30 |
| Speaker | Dr. Ruben Martin, ICIQ, Tarragona, Spain |
| Location | |
| Category | Conferences - Seminars |
Activation of inert entities has been and continues to be of extreme interest to any organic chemist. This is especially true with activation of atmospheric molecules such as CO2 or also the activation of relatively inert C-H, C-C or C-O bonds. Certainly, the development of catalytic methods for the activation of the above-mentioned entities would be highly desirable, as many of the current methods involve the use of stochiometric amounts of metal complexes. Recently, our research group has reported some progress directed towards the activation of inert molecular bonds. Thus, we reported the Pd-catalyzed functionalization of C-H bonds for the synthesis of highly valuable benzocyclobutenones or a-aryl styrenes, the preparation of benzoic acids via direct carboxylation of aryl halides with CO2 and the development of a novel Ni-catalyzed reductive protocol fort he cleavage of inert C-O bonds. These methods are characterized by their wide substrate scope, including challenging substrate combinations with particularly sensitive functional groups and a diverse set of substitution patterns. Additionally, we have performed isotope-labelling experiments that support our initial mechanistic hypothesis in which the key step consists of a metal-catalyzed activation of a C-O or a C-H bond, respectively.
Practical information
- General public
- Free
Organizer
- Hosted by Prof. Xile Hu
Contact
- Professor Xile Hu
[email protected]