Minimally invasive glucose measurement based on interstitial fluid extracted transdermally
Event details
| Date | 04.11.2013 |
| Hour | 11:40 › 12:00 |
| Speaker | Prof. Dachao Li (Tianjin) |
| Location | |
| Category | Conferences - Seminars |
EPFL/IMT - Peking University workshop on MEMS and related technologies
In diabetes care, continuous glucose monitoring of interstitial fluid (ISF) in subcutaneous tissue allows timely detection and correction of abnormal blood glucose excursions. This can be effectively achieved by measuring glucose concentrations in transdermally extracted ISF samples. Recently, MEMS technology has been used to produce miniaturized devices for transdermal ISF extraction and glucose sensing, but there is a lack of on-chip ISF volume measurement capabilities, which are required to compensate for skin permeability variations over time. The enzymatic electrochemical sensor has been commonly realized for glucose monitoring, in which electroactive chemical generation and hydrogen peroxide production may cause erosion of the sensor electrodes and deactivation of the functional enzymes. Also, integration of transdermal ISF extraction and glucose sensing within a single MEMS device has yet to be realized. Here we address these limitations by integrating ISF transdermal extraction, ISF volume measurement, and optical or dielectric glucose sensing in a single lab-on-a-chip system. The single-chip device can potentially enable automated, accurate, and continuous monitoring of subcutaneous ISF glucose concentrations.
Biography:
Dr. Dachao Li received his Ph.D. degree majoring in Precision Instrument and Mechanics at Tianjin University in China in 2004. Then he conducted postdoctoral research at Peking University in China and Case Western Reserve University in USA respectively from 2004 to 2008. Presently, he is an associate professor at the College of Precision Instrument and Optoelectronics Engineering in Tianjin University. His research interests include micro sensors and biomedical micro systems.
In diabetes care, continuous glucose monitoring of interstitial fluid (ISF) in subcutaneous tissue allows timely detection and correction of abnormal blood glucose excursions. This can be effectively achieved by measuring glucose concentrations in transdermally extracted ISF samples. Recently, MEMS technology has been used to produce miniaturized devices for transdermal ISF extraction and glucose sensing, but there is a lack of on-chip ISF volume measurement capabilities, which are required to compensate for skin permeability variations over time. The enzymatic electrochemical sensor has been commonly realized for glucose monitoring, in which electroactive chemical generation and hydrogen peroxide production may cause erosion of the sensor electrodes and deactivation of the functional enzymes. Also, integration of transdermal ISF extraction and glucose sensing within a single MEMS device has yet to be realized. Here we address these limitations by integrating ISF transdermal extraction, ISF volume measurement, and optical or dielectric glucose sensing in a single lab-on-a-chip system. The single-chip device can potentially enable automated, accurate, and continuous monitoring of subcutaneous ISF glucose concentrations.
Biography:
Dr. Dachao Li received his Ph.D. degree majoring in Precision Instrument and Mechanics at Tianjin University in China in 2004. Then he conducted postdoctoral research at Peking University in China and Case Western Reserve University in USA respectively from 2004 to 2008. Presently, he is an associate professor at the College of Precision Instrument and Optoelectronics Engineering in Tianjin University. His research interests include micro sensors and biomedical micro systems.
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- Informed public
- Registration required
- This event is internal
Organizer
- EPFL/IMT