New Catalysts, Methods, and Strategies that Enable Therapeutic Development and On-Demand Natural Product Total Synthesis
Event details
| Date | 06.09.2016 |
| Hour | 17:15 › 18:30 |
| Speaker | Prof. Jeffrey N. Johnston, Vanderbilt University, USA |
| Location |
BCH 2118
|
| Category | Conferences - Seminars |
Small molecules are a mainstay of drug development, offering structural and functional topologies to precisely occupy receptor pockets. Increasingly complex protein-protein interactions demand greater breadth of structural and stereochemical complexity, as well as size, within a discrete compound collection. Furthermore, the incorporation of fluorine into small molecules can provide directed conformational bias, enhance desirable drug like properties, and improve metabolic stability. All of these features are meaningful only when they are at arm’s reach – essentially on-demand – such that attention is focused predominantly on greater issues of potency and selectivity. Tools that enhance the immediacy of availability and acquisition are in high demand.
We have combined new catalyst development with new reaction development to provide unfettered access to a broad range of chiral nonracemic amines, diamines, amino acids, and diverse heterocycles. Our latest work in this area will be described, with an emphasis on the stereocontrolled formation of carbon-heteroatom bonds (C-O, C-N, C-F), unnatural amino acid-containing peptides, and depsipeptides with macrocycles up to 60-atoms in size.
We have combined new catalyst development with new reaction development to provide unfettered access to a broad range of chiral nonracemic amines, diamines, amino acids, and diverse heterocycles. Our latest work in this area will be described, with an emphasis on the stereocontrolled formation of carbon-heteroatom bonds (C-O, C-N, C-F), unnatural amino acid-containing peptides, and depsipeptides with macrocycles up to 60-atoms in size.
Practical information
- General public
- Free
Organizer
- Prof. Jieping Zhu
[email protected]
Contact
- Prof. Jieping Zhu
[email protected]