Nuclear Receptors and Metabolism: From Feast to Famine
Event details
| Date | 22.06.2012 |
| Hour | 16:00 › 17:00 |
| Speaker |
Ronald M. Evans, Professor Director - Gene Expression Laboratory Salk Institute for Biological Studies March of Dimes Chair in Molecular and Developmental Biology HHMI Investigator Howard Hughes Medical Institute - The Salk Institute for Biological Studies, La Jolla, CA - USA web: http://www.salk.edu/faculty/evans.html http://www.hhmi.org/research/investigators/evans_bio.html ----- |
| Location |
SV 1717A
|
| Category | Conferences - Seminars |
Survival requires the ability to adapt to cycles of feast and famine yet the underlying mechanisms to maintain metabolic balance during extremes of nutrient challenge remain poorly understood. As part of a screen to identify genes that respond to feast and famine cues, we discovered that FGF1 is induced in white adipose tissue (WAT) in response to high-fat-diet (HFD) and repressed during a fast, pointing to an unexpected metabolic function. Thus, FGF1 participates in both fed-state and fasted-state responses. In WAT, FGF1 is induced by HFD through a PPAR-gamma dependent mechanism. On HFD, FGF1 deficient mice develop an aggressive diabetic phenotype, with adipose tissue becoming inflamed and unable to adapt to nutrient excess. As loss of FGF1 results in a diabetic phenotype, synthetic FGF1 could be as a new class of insulin sensitizer.
Mammalian metabolism is highly circadian and major hormonal circuits involving nuclear hormone receptors display interlinked diurnal cycling. However, mechanisms that logically explain the coordination of nuclear hormone receptors and the clock are poorly understood. Recently we have shown that two circadian co-regulators, Cryptochrome 1/2 (Cry 1 and 2), and Rev-erb a&b act in the liver to control both lipogenic and gluconeogenic programs. These observations expand our understanding of how metabolism is coordinated with geophysical time.
Mammalian metabolism is highly circadian and major hormonal circuits involving nuclear hormone receptors display interlinked diurnal cycling. However, mechanisms that logically explain the coordination of nuclear hormone receptors and the clock are poorly understood. Recently we have shown that two circadian co-regulators, Cryptochrome 1/2 (Cry 1 and 2), and Rev-erb a&b act in the liver to control both lipogenic and gluconeogenic programs. These observations expand our understanding of how metabolism is coordinated with geophysical time.
Practical information
- General public
- Free
Organizer
- Johan Auwerx for the LSS seminar Series
Contact
- Johan Auwerx