Pd-catalyzed Cross-couplings and Alternatives to Cross-couplings for the (Enantioselective) Alpha Arylation of Aldehydes
Event details
| Date | 05.12.2012 |
| Hour | 17:15 › 18:30 |
| Speaker | Prof. Clément Mazet, University of Geneva, Switzerland |
| Location | |
| Category | Conferences - Seminars |
Depending upon the nature of the substrate the development of efficient transition-metal catalysts for the enantioselective enolate arylation is faced with different but equally challenging issues. On one hand, linear substrates form tertiary alpha-aryl compounds which undergo facile epimerization under the basic conditions generally employed. On the other hand, this problem can be circumvented if alpha-branched substrates are used, but these, in turn, demand the difficult stereoselective formation of more congested quaternary stereocenters.
The nature of the carbonyl functionality comes as a next challenge. Indeed, there is an almost direct relationship between its sensitivity and its synthetic potential and usefulness. In short, the most reactive and sensitive a carbonyl group is, the more versatile and synthetically useful it appears. As a consequence, the catalytic asymmetric alpha-arylation of aldehydes is likely to be the most difficult arylation of enolates to develop.
Current efforts in our group are directed toward the development of methods for the direct (enantioselective) alpha-arylation of aldehydes as well as the development of alternative strategies leading to similar products. A particular emphasis is placed on understanding the mechanism that governs these transformations.Pd-catalyzed Cross-couplings and Alternatives to Cross-couplings for the (Enantioselective) Alpha Arylation of Aldehydes
The nature of the carbonyl functionality comes as a next challenge. Indeed, there is an almost direct relationship between its sensitivity and its synthetic potential and usefulness. In short, the most reactive and sensitive a carbonyl group is, the more versatile and synthetically useful it appears. As a consequence, the catalytic asymmetric alpha-arylation of aldehydes is likely to be the most difficult arylation of enolates to develop.
Current efforts in our group are directed toward the development of methods for the direct (enantioselective) alpha-arylation of aldehydes as well as the development of alternative strategies leading to similar products. A particular emphasis is placed on understanding the mechanism that governs these transformations.Pd-catalyzed Cross-couplings and Alternatives to Cross-couplings for the (Enantioselective) Alpha Arylation of Aldehydes
Practical information
- General public
- Free
Organizer
- Prof. Jérôme Waser
Contact
- Prof. Jérôme Waser
[email protected]