« pH-sensing receptors »
Event details
| Date | 23.10.2009 |
| Hour | 11:30 |
| Speaker | Dr Klaus Seuwen, Principal Research Investigator, Novartis |
| Location |
ROOM : AI 1153
|
| Category | Conferences - Seminars |
G protein-coupled receptors (GPCRs) constitute the largest gene family in mammalian genomes. These receptors and there ligands are involved in the regulation of virtually all physiological processes. The receptors GPR4 and OGR1 (ovarian cancer G protein-coupled receptor 1; GPR68) were identified during efforts to clone new members of the GPCR family. T cell death-associated gene 8 (TDAG8, GPR65) emerged as a gene up-regulated during glucocorticoid treatment of T cells. The three receptors show significant similarity at the amino acid level.
Activating ligands for these receptors remained unknown for several years, until lipid messengers were described as agonists. These findings are today in part withdrawn, and we demonstrated activation of OGR1 and GPR4 by acidic extracellular pH. Other laboratories reported a similar type of regulation for TDAG8.
The physiological roles of the pH-sensing receptors are being elucidated using genetically modified animal models. First data become available from studies with OGR1, GPR4 and TDAG8 knockout animals, and suggest an implication of these receptors in bone & kidney physiology, respiration, endothelial function and immunology.
Practical information
- General public
- Free
Contact
- Prof. Yann Barrandon