Plant receptor kinase-mediated innate immunity
Event details
| Date | 02.02.2016 |
| Hour | 12:15 |
| Speaker | Prof. Cyril Zipfel |
| Location | |
| Category | Conferences - Seminars |
As in animals, the first layer of plant innate immune recognition relies on the perception of pathogen-associated molecular patterns by pattern recognition receptors (PRRs). In plants, all known PRRs are cell surface ligand-binding receptor kinases or receptor-like proteins (which unlike receptor kinases lack an intracellular kinase domain; hence, requiring heteromeric complex formation with accessory receptor kinases). It is now becoming increasingly clear that plant PRRs are part of multimeric protein complexes at the plasma membrane, in a manner similar to the Myddosome for mammalian Toll-like receptors. In my presentation, I will present our recent work that shed light on the molecular mechanisms that control the activation of plant PRR complexes and of downstream cell-autonomous immune responses. In addition, I will illustrate how the use of plant PRRs represents a promising biotechnological tool to engineer disease resistance in crops.
Selected references:
Holton et al., PLoS Pathog., 1(1): e1004602.
Monaghan et al. (2014) Cell Host Microbe, 16(5): 605-615.
Segonzac et al. (2014) EMBO J., 33(18): 2069-2079.
Zipfel (2014) Trends Immunol., 35(7): 345-351.
Macho & Zipfel C (2014) Mol. Cell, 54(2): 263-272.
Kadota et al. (2014) Mol. Cell, 54 (1): 43-55.
Macho et al. (2014) Science, 343 (6178): 1509-1512.
Sun et al. (2013) Science, 342 (6158): 624-628.
Lacombe et al. (2010) Nature Biotech., 28(4): 365-369.
Selected references:
Holton et al., PLoS Pathog., 1(1): e1004602.
Monaghan et al. (2014) Cell Host Microbe, 16(5): 605-615.
Segonzac et al. (2014) EMBO J., 33(18): 2069-2079.
Zipfel (2014) Trends Immunol., 35(7): 345-351.
Macho & Zipfel C (2014) Mol. Cell, 54(2): 263-272.
Kadota et al. (2014) Mol. Cell, 54 (1): 43-55.
Macho et al. (2014) Science, 343 (6178): 1509-1512.
Sun et al. (2013) Science, 342 (6158): 624-628.
Lacombe et al. (2010) Nature Biotech., 28(4): 365-369.
Practical information
- Informed public
- Free
- This event is internal
Organizer
- Global Health Institute