Regulation of protein disaggregation in primates


Event details

Date 21.03.2023
Hour 14:15
Speaker Nadinath B. Nillegoda Centre for Dementia and Brain Repair at the Australian Regenerative Medicine Institute Monash University, Melbourne, Australia
Location Online
Category Conferences - Seminars

Cells have evolved multitiered protein quality control systems to help maintain protein homeostasis, but under acute or chronic proteotoxic stresses, these systems overload and result in accumulation of toxic protein aggregates. Decreased cellular capacity in aggregate clearance could trigger cell dysfunction and death leading to disease and ageing. Human cells possess an Hsp70-based disaggregase system to resolve a wide range of protein aggregates. It is not clear how these disaggregases are assembled and regulated in mammals. We report the identification of a dedicated pathway for rapidly assembling protein disaggregases during stress recovery after protein damage and outlines how aggregate clearance is orchestrated in primate cells. 

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Practical information

  • General public
  • Free