Spike timing and firing rate dependent plasticity as calcium-induced transitions in a bistable synapse model
Event details
| Date | 18.03.2011 |
| Hour | 12:15 |
| Speaker | Nicolas Brunel, CNRS Paris |
| Location | |
| Category | Conferences - Seminars |
Multiple stimulation protocols have been found to be effective in changing synaptic efficacy by inducing long-term potentiation or depression in the hippocampus and neocortex. In many of those protocols, increases in post-synaptic calcium concentration have been shown to play a crucial role. However, it is still unclear whether and how the dynamics of the post-synaptic calcium concentration alone determine the outcome of synaptic plasticity. Here, we investigate numerically and analytically a calcium based model of a synapse in which potentation or depression are described by simple calcium thresholds. We show that this model (i) reproduces the diversity of spike-timing dependent plasticity curves observed in different systems, depending on parameters; (ii) reproduces quantitatively a large number of specific protocols involving more complex spike patterns in hippocampal cultures, and hippocampal and cortical slices.
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Practical information
- General public
- Free
Contact
- Prof. Wulfram GERSTNER