Structure, function and dynamics of Type VI secretion system
Event details
| Date | 07.10.2014 |
| Hour | 12:15 |
| Speaker | Prof. Marek Basler, University of Basel |
| Location | |
| Category | Conferences - Seminars |
Structure, function and dynamics of Type VI secretion system
The bacterial Type VI secretion system (T6SS) is a large dynamic organelle that is functionally analogous to contractile tails of bacteriophages. T6SS is used by Gram-negative bacteria to inhibit adjacent cells via translocation of toxic effector proteins and thus play an important role in bacterial ecology. We used time-lapse fluorescence light microscopy to describe dynamics of Vibrio cholerae T6SS. We showed that T6SS sheath, which powers the secretion, cycles between assembly, quick contraction, and disassembly. Single cell analysis of subcellular localization of T6SS assembly in Pseudomonas aeruginosa revealed that its T6SS organelle is assembled and aimed to specifically retaliate against attacks by other bacteria. I will present latest update on the structure, function and dynamics of T6SS as well on mechanisms of effector delivery.
Marek Basler
Bio: Positions:
Since 2013 Assistant Professor, Biozentrum, University of Basel
2007 – 2013 Postdoctoral Fellow, Department of Microbiology and Immunology, Harvard Medical School, Boston, USA.
Supervisor: John Mekalanos, Ph.D.
Education:
2002 – 2007 Ph.D. studies, Institute of Microbiology, CAS, Prague, Czech Republic. Supervisor: Peter Sebo, Ph.D.
1999 – 2002 Undergraduate studies. Institute of Microbiology, CAS, Prague, Czech Republic.
Supervisor: Peter Sebo, Ph.D.
Selected Awards & Honors:
2009 EMBO long-term fellowship
2006 "Best Young Microbiologist" Award from the Czechoslovak Society for Microbiology
The bacterial Type VI secretion system (T6SS) is a large dynamic organelle that is functionally analogous to contractile tails of bacteriophages. T6SS is used by Gram-negative bacteria to inhibit adjacent cells via translocation of toxic effector proteins and thus play an important role in bacterial ecology. We used time-lapse fluorescence light microscopy to describe dynamics of Vibrio cholerae T6SS. We showed that T6SS sheath, which powers the secretion, cycles between assembly, quick contraction, and disassembly. Single cell analysis of subcellular localization of T6SS assembly in Pseudomonas aeruginosa revealed that its T6SS organelle is assembled and aimed to specifically retaliate against attacks by other bacteria. I will present latest update on the structure, function and dynamics of T6SS as well on mechanisms of effector delivery.
Marek Basler
Bio: Positions:
Since 2013 Assistant Professor, Biozentrum, University of Basel
2007 – 2013 Postdoctoral Fellow, Department of Microbiology and Immunology, Harvard Medical School, Boston, USA.
Supervisor: John Mekalanos, Ph.D.
Education:
2002 – 2007 Ph.D. studies, Institute of Microbiology, CAS, Prague, Czech Republic. Supervisor: Peter Sebo, Ph.D.
1999 – 2002 Undergraduate studies. Institute of Microbiology, CAS, Prague, Czech Republic.
Supervisor: Peter Sebo, Ph.D.
Selected Awards & Honors:
2009 EMBO long-term fellowship
2006 "Best Young Microbiologist" Award from the Czechoslovak Society for Microbiology
Practical information
- Informed public
- Free
Organizer
- John McKinney
Contact
- John McKinney