The DNA Damage Response: Chromatin and Cancer
Event details
| Date | 27.01.2016 |
| Hour | 16:00 › 18:00 |
| Speaker |
Prof. Kyle Miller UT Austin, USA |
| Location | |
| Category | Conferences - Seminars |
Endogenous and exogenous factors are constantly threatening the integrity of our genomes. Cells respond to genetic insults by mounting a complex signaling system collectively termed the DNA damage response (DDR), a network of proteins that function to detect, signal and repair damaged DNA. Many DDR activities take place within chromatin, the protein-DNA complexes that organizes the eukaryotic nuclear genome and regulates both epigenome and genome functions. The structure and function of chromatin are regulated by histone modifications and chromatin modifying enzymes, which can markedly influence the DDR. Therefore, determining the interplay between the DDR and chromatin is fundamental for elucidating how cells maintain both epigenetic and genome integrity. These issues are critical in diseases including cancer where genome and epigenome instability are hallmarks of this disease. In addition, many cancer therapies function through damaging DNA and drugs that target the cancer epigenome are being developed as innovative therapeutic strategies. Therefore, our research aims to understand genome maintenance and the DNA damage response in the context of chromatin, cancer and anticancer therapies. The lab applies a multifaceted and diverse approach including genetics, genomics, cell biology and molecular biology in mammalian cells to study and define the relationship between chromatin and DNA damage responses, as well as to gain insights into the mechanisms of cancer therapeutic drugs that act at the chromatin and DNA level. Our current work related to these topics will be presented.
Practical information
- General public
- Free
Organizer
- Prof. Fierz
Contact
- Marie Munoz