Toward Point-of-Care Assessment of Hemostasis Using Miniaturized Dielectric Coagulometry

Institute of Microengineering - Distinguished Lecture

Campus Lausanne SV 1717 (live)
Campus Microcity MC B0 302 (video)
Zoom Live Stream: https://epfl.zoom.us/j/204283294

Abstract: Point-of-care (POC) diagnostic devices hold great promise to significantly impact healthcare delivery and address health disparities by shifting the focus away from the utilization of high-cost specialized care for the treatment of late-stage diseases toward predictive, preventative, and personalized health for more effective disease monitoring and management. In the developed world, POC technologies are expected to offer effective and feasible means of reducing healthcare costs and improving patient care, whereas in the developing world POC technologies are urgently needed to address pressing healthcare needs with affordable and accessible solutions.
In this lecture, I will first provide a brief overview of the field of POC technologies for health diagnostics. To showcase an example, I will next present our work on ClotChip, a microfluidic sensor that utilizes dielectric spectroscopy for POC assessment of blood coagulation disorders with <10 uL of whole blood. Specifically, I will analyze a simple circuit model that accurately captures the frequency-dependent dielectric behavior of human whole blood placed within a microfluidic channel. I will then discuss how temporal variation in the dielectric properties of the blood sample undergoing coagulation provides information about molecular and cellular abnormalities in the hemostatic process.
Finally, to establish the utility of ClotChip as a platform technology for POC assessment of hemostasis, I will share our results from pilot clinical studies with ClotChip on monitoring anticoagulation therapy with a new class of FDA-approved blood thinners as well as coagulation factor replacement therapy in hemophilia care management. Results from correlative studies between ClotChip and several existing blood coagulation assays are also provided.

Bio: Pedram Mohseni received the B.S. degree from the Sharif University of Technology, Tehran, Iran, in 1996, and the M.S. and Ph.D. degrees from the University of Michigan, Ann Arbor, MI, USA, all in electrical engineering, in 1999 and 2005, respectively. Currently, he is a Professor and Associate Chair in the Electrical Engineering and Computer Science Department at Case Western Reserve University, Cleveland, OH, USA, with a secondary appointment in the Biomedical Engineering Department. His research interests include analog/mixed-signal/RF integrated circuits and microsystems for neural engineering, wireless sensing/actuating systems for brain-machine interfaces, interface circuits for micro/nano-scale sensors/actuators, and point-of-care diagnostic platforms for personalized health. Dr. Mohseni has been an Associate Editor for several IEEE journals since 2008, as well as a member of the Technical Program Committee (TPC) of the IEEE RFIC Symposium (2012-2015), CICC (2012-present), and ISSCC (2017-present). The author of two book chapters, six issued and pending patents, and over 105 refereed technical and scientific articles, he has received several awards including the National Science Foundation CAREER Award, Case School of Engineering Research Award, first-place prize of the Medical Device Entrepreneur’s Forum at the 58th annual conference of the ASAIO, and EECS Mihajlo “Mike” Mesarovic Award for Extraordinary Impact. He has been a member of the IEEE Solid-State Circuits, Circuits and Systems, and Engineering in Medicine and Biology Societies, as well as the administrative committee of the IEEE Sensors Council (2014-2017). Dr. Mohseni was the TPC co-Chair of the IEEE BioCAS conference in 2017 and General co-Chair of the conference in 2018.

Note: The Seminar Series is eligible for ECTS credits in the EDMI doctoral program.