Transcriptional regulation of lipid biosynthesis in mycobacteria
Event details
| Date | 01.12.2011 |
| Hour | 16:00 |
| Speaker | Prof Hugo Gramajo (Instituto de Biologia Molecular y Celular de Rosario, Argentina) |
| Location | |
| Category | Conferences - Seminars |
Mycobacterium tuberculosis remains a major human public health threat. The success of this pathogen largely stems from its remarkable capacity to survive within the infected host, being its unusual cell wall a key factor in this survival. Mycobacteria cell wall biosynthesis involves two structural distinct fatty acid synthase systems, FAS-I and FAS-II, which should work in a finely coordinate manner to keep lipid homeostasis tightly regulated. The main purpose of our studies is to understand how mycobacteria exert this exquisite control over the biosynthesis of their membrane lipids and find out the key components of the regulatory network that control fatty acid and mycolic acid biosynthesis at the transcriptional level. Here, we present the in vivo an in vitro characterization of MabR, the transcriptional regulator of the fasII operon, and of FasR, a new regulatory protein that specifically binds pfas to regulate the de novo fatty acid biosynthesis. We also present evidences that long-chain acyl-CoAs are the effector molecules that co-ordinates the expression of the two FAS systems at the transcriptional level.
Practical information
- General public
- Free
Organizer
- Prof. Stewart Cole
Contact
- Prof. Stewart Cole