Transition-metal-catalyzed Asymmetric Allylic Dearomatization Reactions
Event details
| Date | 12.05.2014 |
| Hour | 17:15 › 18:15 |
| Speaker | Prof. Shuli You, State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China |
| Location | |
| Category | Conferences - Seminars |
Asymmetric dearomatization reactions are particularly attractive methods in organic synthesis given the facts that the starting materials arenes are highly abundant and readily available, and the dearomatization reaction would provide direct access to compounds bearing quaternary carbon center, or polycylces and spirocycles.
In this talk, the progress from the You laboratory on the development of catalytic asymmetric dearomatization processes will be introduced. Direct asymmetric allylic dearomatization reactions of indoles, pyrroles, phenols, naphthols, and pyridines were realized with a proper choice of a catalytic amount of transition-metal catalysts such as Ir, Pd, and Ru complexes. The new ligand design, transformation of the dearomatized products, mechanistic studies and synthetic application will also be discussed.
Reference:
1. (a) Zhang, X.; Han, L.; You, S.-L. Chem. Sci. 2014, 5, in press. (b) Zhuo, C.-X.; You, S.-L. Angew. Chem. Int. Ed. 2013, 52, 10056-10059. (c) Zhuo, C.-X.; Wu, Q.-F.; Zhao, Q.; Xu, Q.-L.; You, S.-L. J. Am. Chem. Soc. 2013, 135, 8169-8172. (d) Liu, W.-B.; Zheng, C.; Zhuo, C.-X.; Dai, L.-X.; You, S.-L. J. Am. Chem. Soc. 2012, 134, 4812-4821. (e) Wu, Q.-F.; Zheng, C.; You, S.-L. Angew. Chem. Int. Ed. 2012, 51, 1680-1683. (f) Zhuo, C.-X.; Liu, W.-B.; Wu, Q.-F.; You, S.-L. Chem. Sci. 2012, 3, 205-208. (g) Wu, Q.-F.; Liu, W.-B.; Zhuo, C.-X.; Rong, Z.-Q.; Ye, K.-Y.; You, S.-L. Angew. Chem. Int. Ed. 2011, 50, 4455-4458. (h) Wu, Q.-F.; He, H.; Liu, W.-B.; You, S.-L. J. Am. Chem. Soc. 2010, 132, 11418-11419.
In this talk, the progress from the You laboratory on the development of catalytic asymmetric dearomatization processes will be introduced. Direct asymmetric allylic dearomatization reactions of indoles, pyrroles, phenols, naphthols, and pyridines were realized with a proper choice of a catalytic amount of transition-metal catalysts such as Ir, Pd, and Ru complexes. The new ligand design, transformation of the dearomatized products, mechanistic studies and synthetic application will also be discussed.
Reference:
1. (a) Zhang, X.; Han, L.; You, S.-L. Chem. Sci. 2014, 5, in press. (b) Zhuo, C.-X.; You, S.-L. Angew. Chem. Int. Ed. 2013, 52, 10056-10059. (c) Zhuo, C.-X.; Wu, Q.-F.; Zhao, Q.; Xu, Q.-L.; You, S.-L. J. Am. Chem. Soc. 2013, 135, 8169-8172. (d) Liu, W.-B.; Zheng, C.; Zhuo, C.-X.; Dai, L.-X.; You, S.-L. J. Am. Chem. Soc. 2012, 134, 4812-4821. (e) Wu, Q.-F.; Zheng, C.; You, S.-L. Angew. Chem. Int. Ed. 2012, 51, 1680-1683. (f) Zhuo, C.-X.; Liu, W.-B.; Wu, Q.-F.; You, S.-L. Chem. Sci. 2012, 3, 205-208. (g) Wu, Q.-F.; Liu, W.-B.; Zhuo, C.-X.; Rong, Z.-Q.; Ye, K.-Y.; You, S.-L. Angew. Chem. Int. Ed. 2011, 50, 4455-4458. (h) Wu, Q.-F.; He, H.; Liu, W.-B.; You, S.-L. J. Am. Chem. Soc. 2010, 132, 11418-11419.
Practical information
- General public
- Free
Organizer
- Prof. Jieping Zhu
[email protected]
Contact
- Prof. Jieping Zhu
[email protected]