Transition Metal-Catalyzed Fluorination of Organic Compounds
Event details
| Date | 08.05.2013 |
| Hour | 17:15 › 18:30 |
| Speaker | Professor Liu Guosheng, State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai |
| Location | |
| Category | Conferences - Seminars |
Transition Metal-Catalyzed Fluorination
Guosheng Liu
State Key Laboratory of Organometallic Chemsitry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
E-mail: [email protected]
Abstract:
Introducing fluorine into organic molecules significantly improves properties such as solubility, bioavailability and metabolic stability, which are of great importance in pharmaceuticals. Despite the utilities of organofluorine compounds, relatively few methods exist for selective carbon–fluorine bond formation, especially when compared to methods for other carbon–halogen bond formations. In recent years, transition metal-catalyzed fluorination of organic compounds has received much attention.
In this talk, I’d like to introduce our efforts in the development palladium- catalyzed fluorination of alkenes, in which two strategies were applied to construct C-F bonds, such as oxidative fluorination of C-Pd bonds, and fluoropalladation of olefins. In addition, more catalytic fluorinations by other metals, such as Ag and Cu, will be discussed as well. Specifically, those catalytic systems could be used to synthesize varieties of fluorinated heterocycles, which might be used as potential skeleton for the new drugs.
Scheme 1: Transition metal-Catalyzed Fluorination
Guosheng Liu
State Key Laboratory of Organometallic Chemsitry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
E-mail: [email protected]
Abstract:
Introducing fluorine into organic molecules significantly improves properties such as solubility, bioavailability and metabolic stability, which are of great importance in pharmaceuticals. Despite the utilities of organofluorine compounds, relatively few methods exist for selective carbon–fluorine bond formation, especially when compared to methods for other carbon–halogen bond formations. In recent years, transition metal-catalyzed fluorination of organic compounds has received much attention.
In this talk, I’d like to introduce our efforts in the development palladium- catalyzed fluorination of alkenes, in which two strategies were applied to construct C-F bonds, such as oxidative fluorination of C-Pd bonds, and fluoropalladation of olefins. In addition, more catalytic fluorinations by other metals, such as Ag and Cu, will be discussed as well. Specifically, those catalytic systems could be used to synthesize varieties of fluorinated heterocycles, which might be used as potential skeleton for the new drugs.
Scheme 1: Transition metal-Catalyzed Fluorination
Practical information
- General public
- Free
Organizer
- Professor Xile Hu
Contact
- Professor Xile Hu
[email protected]