Ubiquitin-mediated Regulation of Cell Death and Inflammation in Cancer
Event details
| Date | 20.01.2014 |
| Hour | 14:00 › 15:00 |
| Speaker | Prof. Pascal Meier |
| Location | |
| Category | Conferences - Seminars |
The association of inflammation with cancer remains an unsolved mystery of current biology and medicine. While inflammation is a protective response to noxious stimuli, smouldering inflammation in the tumour microenvironment can support tumour growth, subvert adaptive immunity, and response to therapy. Recent evidence indicate that a complex relationship exists between components of the cell death pathways and inflammation. Inhibitor of APoptosis (IAP) proteins represent key regulators of both cell death and inflammatory signalling. IAPs are implicated in cancer due to their ability to inhibit cell death but also because they mediate activation of NFκB and MAPK pathways that, in turn, drive expression of genes important for cell survival, inflammation, immunity and cell migration. Here, I will review the Ubiquitin-dependent functions assigned to those IAP proteins that act at the intersection of cell death regulation and inflammatory signaling, and discuss some unexpected non-apoptotic roles of components of the cell death machinery.
Practical information
- General public
- Free
Organizer
- Prof. Bruno Lemaitre
Contact
- Prof. Bruno Lemaitre