Understanding the Genotype to Phenotype Transformation for Cholesterol Regulation
Event details
| Date | 25.11.2013 |
| Hour | 11:00 › 12:00 |
| Speaker |
Dr. Peter Blattmann, Institute of Molecular Systems Biology, Group of Prof. Ruedi Aebersold, ETH, Zurich Bio: Dr. Blattmann studied biochemistry at the ETH Zurich and during his Master thesis he worked on the endocytosis pathway of Human Papillomavirus in the Helenius lab. After his studies, he performed an internship at Genentech in South San Francisco where he worked on the interaction of viruses with dendritic cells. In 2008, he received a Fellowship with the European Molecular Biology Laboratory (EMBL) for his PhD. His PhD thesis, entitled “Identification and Characterization of Novel Cellular Cholesterol Regulators”, was performed in the Molecular Medicine Partnership Unit (MMPU) between EMBL and the University Hospital Heidelberg in the groups of Dr. Rainer Pepperkok and Dr. Heiko Runz. It consisted of a systematic study using RNA interference and functional assays assessing cellular cholesterol uptake in order to profile the genes reported by Genome-wide association studies (GWAS) for blood lipid traits and cardiovascular disease. He joined the Aebersold lab in May 2013 to analyze cholesterol regulation using mass-spectrometry based methods. |
| Location | |
| Category | Conferences - Seminars |
A seminar of the Lausanne Integrative Metabolism and Nutrition Alliance (LIMNA)
Abstract:
Cellular cholesterol regulation is a biological process underlying the complex diseases of elevated blood lipid levels and cardiovascular disease in humans. Recent Genome-wide association studies (GWAS) have identified many associated loci in the genome. However, how the proteins encoded in these loci interact functionally in order to lead to a complex phenotype is currently unknown. In this talk, I will outline how we are combining state of the art targeted mass-spectrometry and modeling in order to understand better the complex network of cholesterol regulation.
Abstract:
Cellular cholesterol regulation is a biological process underlying the complex diseases of elevated blood lipid levels and cardiovascular disease in humans. Recent Genome-wide association studies (GWAS) have identified many associated loci in the genome. However, how the proteins encoded in these loci interact functionally in order to lead to a complex phenotype is currently unknown. In this talk, I will outline how we are combining state of the art targeted mass-spectrometry and modeling in order to understand better the complex network of cholesterol regulation.
Links
Practical information
- Informed public
- Free
Organizer
- Kristina Schoonjans and Johan Auwerx for the LIMNA Alliance
Contact
- Johan Auwerx