BMI Seminar // Insulin signaling and compulsivity: a translational perspective
Event details
| Date | 01.03.2017 |
| Hour | 12:15 › 13:15 |
| Speaker | Jeffrey Glennon, Dept. of Cognitive Neuroscience, Donders Institute, Radboud University Medical Center, Nijmegen, Netherlands |
| Location | |
| Category | Conferences - Seminars |
Obsessive compulsive disorder (OCD) is characterized by compulsive behavior punctuated by anxiety-driven obsessive episodes. A genetic network based approach was utilized to construct a genetic landscape of human OCD related targets based on pathway (IPA; WebGestalt) and gene ontology analysis of 2 genome wide association studies (GWAS) of OCD which highlighted the role of 66 candidate genes. Of these, several were associated with insulin signaling including IGF1 and KCNQ1. Furthermore, expression of microRNA associated with insulin signaling (miRs 128, 129, 221 and 455) were increased in a rat OCD model of compulsive lever pressing (signal attenuation). Increased insulin resistance may be key to compulsive behavior, as impaired spontaneous alternation, reversal learning and extinction were observed in a Type II diabetes animal model (the TALLYHO mice) which were correlated with decreased cerebellar IGF1 protein levels. No effect was seen in a Type I diabetes model (Alloxan treated mice). Finally, a current front-line type II diabetes medication (which decreases insulin resistance) metformin in pilot studies demonstrates a marked reduction in quinpirole-induced compulsive checking in rats. Proxy genetic, microRNA and MRI-DTI structural connectivity markers are currently under investigation.
Practical information
- Informed public
- Free
Organizer
- SV - BMI
Host : C. Sandi