Alice’s cake for NMR: enhanced polarisation and extended spin memory to address large biomolecules
Event details
| Date | 29.03.2010 |
| Hour | 16:15 |
| Speaker | Dr. Paul R. Vasos |
| Location |
CE 4 - Centre Est EPFL
|
| Category | Conferences - Seminars |
In order to reach beyond the current molecular size and timescale limits of structural and dynamic studies, NMR requires enhanced sensitivity, resolution, and spin-order lifetimes. To answer these challenges, we have to find ways that go further than increasing the strength of the static magnetic fields.
In order to improve the resolution and sensitivity of liquid-state NMR measurements, we have used long-lived magnetisation states shaped to yield narrow and intense signals upon Fourier transform. This opens the way for studies of biomolecules one order of magnitude larger than the current threshold. Dynamic nuclear polarization (DNP) has been used to couple nuclear spins to the large population reservoir of electrons and thereby considerably enhance the sensitivity of NMR measurements. Enhanced solid-state NMR holds the promise of obtaining atomic-resolution information from biomolecules that are challenging to crystallise. The latest achievements in this area at EPFL will be presented.
Practical information
- General public
- Free