ChemBio Seminar by Dr. Takeshi Harayama (Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur, France)
Event details
| Date | 12.11.2024 |
| Hour | 15:00 › 16:00 |
| Speaker | Dr. Takeshi Harayama |
| Location | |
| Category | Conferences - Seminars |
| Event Language | English |
Title:
Connecting lipid tail structures to cellular functions
Abstract:
Cellular membranes are composed of a diverse set of lipids with tails that vary significantly in chain lengths, the number of double bonds and the positions of these double bonds. Although lipids with uniform tails are sufficient to make bilayers in vitro, the diversity in lipid tail structures is seen across the tree of life, suggesting the biological importance of having lipids with distinct tails. It is critical to decode the functional relevance of lipid tails to understand the basic architecture of our cells, and to correctly assess the importance of lipidome changes that are seen in various diseases. For this, we are developing tools that combine genetics and synthetic lipid feeding to manipulate the tail composition of membrane lipids in cells, allowing us to study their consequences. In this seminar, I will discuss how an optimal combination of lipid head groups and tails is generated in cells, and how they contribute to cellular processes, such as ferroptosis, which is a lipid peroxidation-dependent cell death.
Speaker:
2020-now Group Leader, Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur - CNRS - Inserm, France
2015-2020 Postdoctoral researcher, Biochemistry department, University of Geneva, Switzerland (Howard Riezman lab)
2011-2015 Postdoctoral researcher, University of Tokyo and National Center for Global Health and Medicine, Japan (Takao Shimizu lab)
2011 Ph.D. (Graduate School of Medicine, The University of Tokyo, Japan, Takao Shimizu lab)
Connecting lipid tail structures to cellular functions
Abstract:
Cellular membranes are composed of a diverse set of lipids with tails that vary significantly in chain lengths, the number of double bonds and the positions of these double bonds. Although lipids with uniform tails are sufficient to make bilayers in vitro, the diversity in lipid tail structures is seen across the tree of life, suggesting the biological importance of having lipids with distinct tails. It is critical to decode the functional relevance of lipid tails to understand the basic architecture of our cells, and to correctly assess the importance of lipidome changes that are seen in various diseases. For this, we are developing tools that combine genetics and synthetic lipid feeding to manipulate the tail composition of membrane lipids in cells, allowing us to study their consequences. In this seminar, I will discuss how an optimal combination of lipid head groups and tails is generated in cells, and how they contribute to cellular processes, such as ferroptosis, which is a lipid peroxidation-dependent cell death.
Speaker:
2020-now Group Leader, Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur - CNRS - Inserm, France
2015-2020 Postdoctoral researcher, Biochemistry department, University of Geneva, Switzerland (Howard Riezman lab)
2011-2015 Postdoctoral researcher, University of Tokyo and National Center for Global Health and Medicine, Japan (Takao Shimizu lab)
2011 Ph.D. (Graduate School of Medicine, The University of Tokyo, Japan, Takao Shimizu lab)
Practical information
- Informed public
- Free
Organizer
- Dr. Milena Schuhacher