ChemBio Seminar by Prof. Jeremy Baskin (Cornell University, USA)
Event details
| Date | 08.04.2025 |
| Hour | 16:00 › 17:00 |
| Location | |
| Category | Conferences - Seminars |
| Event Language | English |
Title: Imaging, Editing, and Deciphering the Lipidome
Speaker: Jeremy M. Baskin is Associate Professor, Nancy and Peter Meinig Family Investigator in the Life Sciences, and Director of the Chemistry–Biology Interface Program at Cornell University, with appointments in the Department of Chemistry and Chemical Biology and the Weill Institute for Cell and Molecular Biology. He was born and raised in Montreal, Canada and received his undergraduate education at the Massachusetts Institute of Technology, with a major in Chemistry and minors in Biology and Music. Jeremy carried out Ph.D. studies supported by NDSEG and NSF graduate fellowships in Carolyn Bertozzi’s group at the University of California, Berkeley, focusing on development of bioorthogonal chemistries. Jeremy received postdoctoral training in cell biology as a Jane Coffin Childs fellow at Yale University with Pietro De Camilli. Research in the Baskin lab centers on the chemical biology and cell biology of lipid signaling, with a focus both on development of tools for imaging and editing cellular lipids and elucidation of mechanisms underlying physiological and pathological lipid metabolism and signaling events. Jeremy has been the recipient of numerous awards, including Beckman Young Investigator, Sloan Research Fellowship, NSF CAREER, ACS Young Academic Investigator, ASBMB Walter A. Shaw Young Investigator in Lipid Research, and ICBS Young Chemical Biologist Award.
Abstract: Phospholipids are the major constituents of cellular membranes and also important signaling molecules. Because these hydrophobic metabolites are not directly genetically encoded, their detection and precise manipulation with traditional genetic methods is challenging. Therefore, chemical methods for detecting the biosynthesis and intracellular transport of lipids, as well as those for modulating their levels with a high degree of spatiotemporal control, are urgently needed. I will highlight our latest advances in applying bioorthogonal chemistry, activity-based imaging, protein engineering, directed evolution, and optogenetics toward the development of small molecule-based tools for visualizing phospholipid biosynthesis and interorganelle transport. As well, I will describe light-controlled enzymes that we term membrane editors for precise manipulation of the lipid composition of target organelle membranes in live cells, with a focus throughout on strategies for tool development and biological applications to reveal insights into regulation of lipid metabolism, transport, signaling, and interactions with the proteome.
Speaker: Jeremy M. Baskin is Associate Professor, Nancy and Peter Meinig Family Investigator in the Life Sciences, and Director of the Chemistry–Biology Interface Program at Cornell University, with appointments in the Department of Chemistry and Chemical Biology and the Weill Institute for Cell and Molecular Biology. He was born and raised in Montreal, Canada and received his undergraduate education at the Massachusetts Institute of Technology, with a major in Chemistry and minors in Biology and Music. Jeremy carried out Ph.D. studies supported by NDSEG and NSF graduate fellowships in Carolyn Bertozzi’s group at the University of California, Berkeley, focusing on development of bioorthogonal chemistries. Jeremy received postdoctoral training in cell biology as a Jane Coffin Childs fellow at Yale University with Pietro De Camilli. Research in the Baskin lab centers on the chemical biology and cell biology of lipid signaling, with a focus both on development of tools for imaging and editing cellular lipids and elucidation of mechanisms underlying physiological and pathological lipid metabolism and signaling events. Jeremy has been the recipient of numerous awards, including Beckman Young Investigator, Sloan Research Fellowship, NSF CAREER, ACS Young Academic Investigator, ASBMB Walter A. Shaw Young Investigator in Lipid Research, and ICBS Young Chemical Biologist Award.
Abstract: Phospholipids are the major constituents of cellular membranes and also important signaling molecules. Because these hydrophobic metabolites are not directly genetically encoded, their detection and precise manipulation with traditional genetic methods is challenging. Therefore, chemical methods for detecting the biosynthesis and intracellular transport of lipids, as well as those for modulating their levels with a high degree of spatiotemporal control, are urgently needed. I will highlight our latest advances in applying bioorthogonal chemistry, activity-based imaging, protein engineering, directed evolution, and optogenetics toward the development of small molecule-based tools for visualizing phospholipid biosynthesis and interorganelle transport. As well, I will describe light-controlled enzymes that we term membrane editors for precise manipulation of the lipid composition of target organelle membranes in live cells, with a focus throughout on strategies for tool development and biological applications to reveal insights into regulation of lipid metabolism, transport, signaling, and interactions with the proteome.
Practical information
- Informed public
- Free
Organizer
- Milena Schuhmacher
Contact
- milena.schuhmacher@epfl.ch