Chemical Evolution of Natural Product Structure


Event details

Date 21.09.2021
Hour 16:1517:15
Speaker Prof. Herbert Waldmann, Max Planck Insitute of Molecular Physiology
Location Online
Category Conferences - Seminars
Event Language English

Natural products have provided inspiration for chemical biology and medicinal chemistry research. However, their often complex structure, and, therefore, demanding synthesis as well as their frequent unavailability, hamper their application.
This raises the fundamental question whether the particular structural and biological properties of natural products can be translated to structurally less demanding compounds, readily accessible by chemical synthesis and yet still endowed with pronounced bioactivity.
The lecture will describe a logic for the simplification of natural product structure by means of “Biology Oriented Synthesis” (BIOS) and its evolution into the “Pseudo Natural Product” (PNP) concept. Application of natural product inspired compound collections designed and synthesized following these principles in cell-based phenotypic assays and subsequent identification of the cellular target proteins demonstrate that the BIOS and PNPs may enable innovation in both chemical biology and medicinal chemistry research.

Practical information

  • Informed public
  • Free


  • Christian Heinis