Chlamydia is a Master Cell Biologist: The Secret Lives of Intracellular Pathogens
Event details
| Date | 17.07.2018 |
| Hour | 12:15 |
| Speaker | Joanne Engel, Director, Microbial Pathogenesis and Host Defense Program, University of California, San Francisco (UCSF) |
| Location | |
| Category | Conferences - Seminars |
Chlamydia trachomatis is a leading cause of genital and ocular infections for which no vaccine exists. Upon entry into host cells, C. trachomatis resides within a membrane-bound compartment — the inclusion — and secretes inclusion membrane proteins (Incs) that are thought to modulate the host-bacterium Interface. In the absence, until recently, of being able to genetically manipulate Chlamydia, we used high through-put affinity purification/mass spectroscopy to identify potential host binding partners for the Incs to infer and explore their function. We have identified high confidence host protein interactors for ~2/3 of the Incs and will discuss potential interactions with retromer-dependent vesicular trafficking and dynactin function at the centrosome. This study demonstrates the value of proteomics in unveiling hos-tpathogen interactions in genetically challenging microbes.
Practical information
- Informed public
- Free
Organizer
- Alexandre Persat