CIS - "Get to know your neighbors" Seminar series - Prof. Matteo Dal Peraro
Event details
| Date | 30.05.2022 |
| Hour | 15:15 › 16:15 |
| Speaker | Prof. Matteo Dal Peraro |
| Location | Online |
| Category | Conferences - Seminars |
| Event Language | English |
From Integrative Structural Biology to Bioengineering
Abstract:
Proteins are the major molecular building blocks of life, dictating the spatial and temporal occurrence of most biological functions. They ultimately encode the genetic information of every organism and translate it into the physical and chemical mechanisms at the basis of all the molecular processes sustaining living organisms. They have evolved to do so by specifically interacting with other proteins, nucleic acids, metabolites, membranes in order to form supramolecular complexes whose structural architecture is at basis of their biological function.
In my lab we study the emergence of macromolecular function from its structural organization and native dynamics by integrating experimental data with molecular models and simulations. Recently, leveraging advances in computer vision and artificial intelligence, we have developed methods to efficiently address the outstanding problems of fitting molecular models into low-resolution cryo-electron microscopy data and predicting protein interacting interfaces.
Eventually, the knowledge we gain at this fundamental level is used to exploit the properties of these molecular assemblies, like in the case of biological pores that we engineer with the purpose of characterizing the same biological matter they are made of.
Bio:
Matteo Dal Peraro graduated in Physics at the University of Padua in 2000. He obtained his Ph.D. in Biophysics at the International School for Advanced Studies (SISSA, Trieste) in 2004. He then received postdoctoral training at the University of Pennsylvania (Philadelphia). He joined EPFL School of Life Sciences in late 2007. His research at the Laboratory for Biomolecular Modeling (LBM), within the Institute of Bioengineering (IBI), now focuses on integrative structural biology and nanopore sensing. He served as Director of the Doctoral Programs in Biotechnology and Bioengineering (EDBB) and in Computational and Quantitative Biology (EDCB) and currently is the Associate Director of the Institute of Bioengineering (IBI).
The Center for Intelligent Systems at EPFL (CIS) is a collaboration among IC, ENAC, SB; SV and STI that brings together researchers working on different aspects of Intelligent Systems.
In order to promote exchanges among researchers and encourage the creation of new, collaborative projects, CIS is organizing a "Get to know your neighbors" series. Each seminar will consist of one short overview presentation geared to the general public at EPFL.
The CIS seminar will take place In hybrid mode: Room INF 328 and by Zoom: https://epfl.zoom.us/j/66077101128
Please connect to your zoom account using your "@epfl.ch" address, as this live event is only open to the EPFL community
Monday, May 30th, 2022 from 3:15 to 4:15 pm
NB: Video recordings of the seminars will be made available on our website and published on our social media pages
Abstract:
Proteins are the major molecular building blocks of life, dictating the spatial and temporal occurrence of most biological functions. They ultimately encode the genetic information of every organism and translate it into the physical and chemical mechanisms at the basis of all the molecular processes sustaining living organisms. They have evolved to do so by specifically interacting with other proteins, nucleic acids, metabolites, membranes in order to form supramolecular complexes whose structural architecture is at basis of their biological function.
In my lab we study the emergence of macromolecular function from its structural organization and native dynamics by integrating experimental data with molecular models and simulations. Recently, leveraging advances in computer vision and artificial intelligence, we have developed methods to efficiently address the outstanding problems of fitting molecular models into low-resolution cryo-electron microscopy data and predicting protein interacting interfaces.
Eventually, the knowledge we gain at this fundamental level is used to exploit the properties of these molecular assemblies, like in the case of biological pores that we engineer with the purpose of characterizing the same biological matter they are made of.
Bio:
Matteo Dal Peraro graduated in Physics at the University of Padua in 2000. He obtained his Ph.D. in Biophysics at the International School for Advanced Studies (SISSA, Trieste) in 2004. He then received postdoctoral training at the University of Pennsylvania (Philadelphia). He joined EPFL School of Life Sciences in late 2007. His research at the Laboratory for Biomolecular Modeling (LBM), within the Institute of Bioengineering (IBI), now focuses on integrative structural biology and nanopore sensing. He served as Director of the Doctoral Programs in Biotechnology and Bioengineering (EDBB) and in Computational and Quantitative Biology (EDCB) and currently is the Associate Director of the Institute of Bioengineering (IBI).
The Center for Intelligent Systems at EPFL (CIS) is a collaboration among IC, ENAC, SB; SV and STI that brings together researchers working on different aspects of Intelligent Systems.
In order to promote exchanges among researchers and encourage the creation of new, collaborative projects, CIS is organizing a "Get to know your neighbors" series. Each seminar will consist of one short overview presentation geared to the general public at EPFL.
The CIS seminar will take place In hybrid mode: Room INF 328 and by Zoom: https://epfl.zoom.us/j/66077101128
Please connect to your zoom account using your "@epfl.ch" address, as this live event is only open to the EPFL community
Monday, May 30th, 2022 from 3:15 to 4:15 pm
NB: Video recordings of the seminars will be made available on our website and published on our social media pages
Practical information
- General public
- Free
Organizer
- CIS