Gene Regulation and Phenotypic Memory in Fluctuating Environments
Event details
| Date | 11.07.2023 |
| Hour | 12:15 › 13:15 |
| Speaker | Edo Kussell, Departments of Biology and Physics, New York University |
| Location | |
| Category | Conferences - Seminars |
| Event Language | English |
Bacterial survival in fluctuating environments relies on gene regulatory mechanisms that activate and repress specific genes in response to environmental cues. By measuring growth of bacteria in a fluctuating environment using microfluidic devices, we have found that phenotypic memory coupled with gene regulation in the sugar operons of Escherichia coli increases long-term growth rates. In this talk, I will describe the molecular basis of phenotypic memory in the lac operon, and present results on the competitive advantage of different levels of memory in a periodically changing environment. In the context of metabolic fluctuations, I will discuss the question of how selection maintains a gene regulatory mechanism and acts on gene expression levels to enhance phenotypic memory.
Practical information
- Informed public
- Free
Organizer
- John McKinney