Imaging Seminar: Unique X-ray microscopy capabilities at SLS2.0: dynamic tomographic imaging and beyond
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Abstract:
Over 125 years have passed since W. Röntgen's groundbreaking discovery of X-rays. Today, scientists worldwide continue to explore the full potential of X-ray imaging by harnessing the advanced capabilities of the latest generation synchrotron facilities. Contemporary X-ray micro- and nanoimaging techniques heavily rely on the unique properties of synchrotron beams, precise optical systems, and sophisticated algorithms. These tools enable researchers to detect minute disturbances in wavefronts caused by samples, ultimately leading to the reconstruction of their internal structures.
Remarkable advancements have pushed the boundaries of tomographic microscopy, achieving isotropic resolutions as fine as a few tens of nanometers. Additionally, the speed of tomographic scans has reached unprecedented levels, allowing for thousands of tomograms to be generated per second. These breakthroughs have paved the way for an array of exciting applications, such as real-time observation of complex biomechanical processes in small animals, comprehensive mapping of the microvasculature in a mouse's brain, visualizing the dynamic dissolution of tablets, and investigating intricate rheological phenomena in soft materials. Precise control, and synchronization of mechanical, thermal, or chemical stimuli are necessary. Accurate temporal alignment between the applied stimuli and imaging frames is essential to unravel the underlying mechanisms. Developing synchronized experimental setups, precise triggering mechanisms, and real-time feedback control systems are key to achieving reliable and reproducible results. Finally, the vast amount of data generated during these experiments presents challenges for data handling, storage, and analysis. High-throughput data acquisition demands robust data management systems and sophisticated computational tools for image reconstruction, segmentation, and quantification. Advanced algorithms capable of handling large datasets, accounting for time-dependent changes in the sample's microstructure, and extracting meaningful information are crucial for successful analysis.During the presentation, I will delve into the cutting-edge world of X-ray tomographic imaging at the Swiss Light Source (SLS). Furthermore, I will present future capabilities enabled by the TOMCAT2.0 beamline, a flagship project within the major SLS2.0 upgrade program.
Bio:
Marco Stampanoni has been Assistant Professor (2008-2013), Associate Professor (2013-2017) and since 2017 Full Professor for X-Ray Imaging at ETH Zurich, within the Department of Information Technology and Electrical Engineering at ETH Zurich. His professorship is affiliated to the Institute of Biomedical Engineering of the University and ETH Zurich, where he leads the division for X-ray Imaging and Microscopy. At the Paul Scherrer Institut, he is the head of the X-ray tomography group at the Swiss Light Source (SLS). Born on May 10, 1974 in Lugano (Ticino, Switzerland) Marco Stampanoni studied physics at the ETH Zurich. After receiving his diploma in 1998, he graduated at the ETH in 2002 with a thesis on synchrotron-based tomographic microscopy. For his PhD, he received the ETH silver medal in 2003. From 1998 to 2000 he successfully followed a post-graduate course in Medical Physics. In 2002 he started as an Instrument Scientist at the Swiss Light Source (SLS) of the Paul Scherrer Institut in Villigen, Switzerland. In 2004 he was nominated beamline scientist and responsible for the development and realization of a tomography dedicated beamline at the SLS. In 2005 he was elected Head of the "X-ray Tomography Group" of the SLS. In 2008 he was appointed Assistant Professor (Tenure Track) for X-ray Microscopy at the ETH Zurich and, in 2010, Director of the ETH-Master of Advanced Studies (MAS) in Medical Physics. In 2012 he received an ERC Grant for his project on phase contrast X-ray imaging and won the “Dalle Molle Foundation Award” for his pioneering work on X-ray phase contrast mammography. He was among the three finalists of the “European Inventor Award 2022” and the recipient of the “Giuseppe Sciacca International Award 2022” for biomedical research. He is teaching at ETH Zurich in the field of X-ray microscopy. Since 2018 he is the President of the Research Commission of the Paul Scherrer Institut.
Registration appreciated
More info here
Abstract:
Over 125 years have passed since W. Röntgen's groundbreaking discovery of X-rays. Today, scientists worldwide continue to explore the full potential of X-ray imaging by harnessing the advanced capabilities of the latest generation synchrotron facilities. Contemporary X-ray micro- and nanoimaging techniques heavily rely on the unique properties of synchrotron beams, precise optical systems, and sophisticated algorithms. These tools enable researchers to detect minute disturbances in wavefronts caused by samples, ultimately leading to the reconstruction of their internal structures.
Remarkable advancements have pushed the boundaries of tomographic microscopy, achieving isotropic resolutions as fine as a few tens of nanometers. Additionally, the speed of tomographic scans has reached unprecedented levels, allowing for thousands of tomograms to be generated per second. These breakthroughs have paved the way for an array of exciting applications, such as real-time observation of complex biomechanical processes in small animals, comprehensive mapping of the microvasculature in a mouse's brain, visualizing the dynamic dissolution of tablets, and investigating intricate rheological phenomena in soft materials. Precise control, and synchronization of mechanical, thermal, or chemical stimuli are necessary. Accurate temporal alignment between the applied stimuli and imaging frames is essential to unravel the underlying mechanisms. Developing synchronized experimental setups, precise triggering mechanisms, and real-time feedback control systems are key to achieving reliable and reproducible results. Finally, the vast amount of data generated during these experiments presents challenges for data handling, storage, and analysis. High-throughput data acquisition demands robust data management systems and sophisticated computational tools for image reconstruction, segmentation, and quantification. Advanced algorithms capable of handling large datasets, accounting for time-dependent changes in the sample's microstructure, and extracting meaningful information are crucial for successful analysis.During the presentation, I will delve into the cutting-edge world of X-ray tomographic imaging at the Swiss Light Source (SLS). Furthermore, I will present future capabilities enabled by the TOMCAT2.0 beamline, a flagship project within the major SLS2.0 upgrade program.
Bio:
Marco Stampanoni has been Assistant Professor (2008-2013), Associate Professor (2013-2017) and since 2017 Full Professor for X-Ray Imaging at ETH Zurich, within the Department of Information Technology and Electrical Engineering at ETH Zurich. His professorship is affiliated to the Institute of Biomedical Engineering of the University and ETH Zurich, where he leads the division for X-ray Imaging and Microscopy. At the Paul Scherrer Institut, he is the head of the X-ray tomography group at the Swiss Light Source (SLS). Born on May 10, 1974 in Lugano (Ticino, Switzerland) Marco Stampanoni studied physics at the ETH Zurich. After receiving his diploma in 1998, he graduated at the ETH in 2002 with a thesis on synchrotron-based tomographic microscopy. For his PhD, he received the ETH silver medal in 2003. From 1998 to 2000 he successfully followed a post-graduate course in Medical Physics. In 2002 he started as an Instrument Scientist at the Swiss Light Source (SLS) of the Paul Scherrer Institut in Villigen, Switzerland. In 2004 he was nominated beamline scientist and responsible for the development and realization of a tomography dedicated beamline at the SLS. In 2005 he was elected Head of the "X-ray Tomography Group" of the SLS. In 2008 he was appointed Assistant Professor (Tenure Track) for X-ray Microscopy at the ETH Zurich and, in 2010, Director of the ETH-Master of Advanced Studies (MAS) in Medical Physics. In 2012 he received an ERC Grant for his project on phase contrast X-ray imaging and won the “Dalle Molle Foundation Award” for his pioneering work on X-ray phase contrast mammography. He was among the three finalists of the “European Inventor Award 2022” and the recipient of the “Giuseppe Sciacca International Award 2022” for biomedical research. He is teaching at ETH Zurich in the field of X-ray microscopy. Since 2018 he is the President of the Research Commission of the Paul Scherrer Institut.
Registration appreciated
More info here
Practical information
- General public
- Free
Organizer
- EPFL Center for Imaging