Novel Applications of Human Liver Chimeric Mice
Event details
| Date | 07.08.2015 |
| Hour | 11:00 › 12:00 |
| Speaker | Prof. Karl-Dimiter Bissig, Baylor College of Medicine |
| Location | |
| Category | Conferences - Seminars |
Since the first description of human liver chimeric mice, there have been many applications of this versatile small animal model. In this talk, I will present two new applications of human liver chimeric mice. By transplanting diseased human hepatocytes from a metabolic disease patient (familial hypercholesterolemia), we have managed to induce human disease in murine hosts and thereby have established the first xenograft model for human metabolic liver disease. Further, we were able to rescue the disease phenotype with an experimental gene therapy. I will also introduce a new liver cancer model, which faithfully mimics human disease and is in many ways superior to current cancer models.
Practical information
- General public
- Free
- This event is internal
Organizer
- Marco Cassano, Prof. Didier Trono