Shedding Light on Tumour Evolution
Event details
Date | 27.11.2020 |
Hour | 17:00 › 18:00 |
Speaker | Prof. Sarah Bohndiek, University of Cambridge |
Location | Online |
Category | Conferences - Seminars |
This event is part of the EPFL Seminar Series in Imaging (https://imagingseminars.org).
Abstract. The dynamic cellular ecosystem of a growing tumour mass requires a vascular network to obtain oxygen and nutrients, as well as to remove metabolic waste products. Early in their development, tumours stimulate new blood vessel growth through a range of mechanisms to meet this need, leading to marked differences in the vasculature between normal and tumour tissue that could be exploited for early cancer detection and monitoring of therapy response. These differences in vascular phenotypes can be revealed using optics, thanks to the strong absorption of light by oxy- and deoxy-haemoglobin.
In this talk, I will introduce our efforts to harness next-generation imaging sciences to visualise tumour architecture and function non-invasively. In particular, I will introduce photoacoustic imaging and explain how its multiscale implementations can provide insight into vascular evolution and remodelling in response to treatment in animal models. I will then provide an overview of the future clinical challenges and opportunities in using photoacoustic imaging in patients.
Biography. Prof. Sarah Bohndiek is Group Leader at the University of Cambridge, where she is jointly appointed in the Department of Physics and the Cancer Research UK Cambridge Institute. The broad mission of Sarah’s interdisciplinary team, the VISIONLab, is advance our understanding of tumour evolution using next-generation imaging sciences. They are also are active in translating their findings into clinical trials. Sarah was recently awarded the CRUK Future Leaders in Cancer Research Prize and SPIE Early Career Achievement Award in recognition of her interdisciplinary research innovation.
Abstract. The dynamic cellular ecosystem of a growing tumour mass requires a vascular network to obtain oxygen and nutrients, as well as to remove metabolic waste products. Early in their development, tumours stimulate new blood vessel growth through a range of mechanisms to meet this need, leading to marked differences in the vasculature between normal and tumour tissue that could be exploited for early cancer detection and monitoring of therapy response. These differences in vascular phenotypes can be revealed using optics, thanks to the strong absorption of light by oxy- and deoxy-haemoglobin.
In this talk, I will introduce our efforts to harness next-generation imaging sciences to visualise tumour architecture and function non-invasively. In particular, I will introduce photoacoustic imaging and explain how its multiscale implementations can provide insight into vascular evolution and remodelling in response to treatment in animal models. I will then provide an overview of the future clinical challenges and opportunities in using photoacoustic imaging in patients.
Biography. Prof. Sarah Bohndiek is Group Leader at the University of Cambridge, where she is jointly appointed in the Department of Physics and the Cancer Research UK Cambridge Institute. The broad mission of Sarah’s interdisciplinary team, the VISIONLab, is advance our understanding of tumour evolution using next-generation imaging sciences. They are also are active in translating their findings into clinical trials. Sarah was recently awarded the CRUK Future Leaders in Cancer Research Prize and SPIE Early Career Achievement Award in recognition of her interdisciplinary research innovation.
Practical information
- General public
- Free
Organizer
- Imaging@EPFL
Contact
- Laurène Donati