Toward a renewed understanding of host defenses against microbial infections in Drosophila
Drosophila melanogaster is a potent genetic model to investigate host defenses against infections and to decipher mechanisms of innate immunity. The current paradigm is that upon the sensing of infectious microbes present in the internal body cavity of the fly, the NF-kB-type signal transduction pathways Toll and Immune deficiency are activated in the fat body and lead to the release in the hemolymph of multiple secreted peptides, many of which have been shown to act as antimicrobial peptides.
We are interested in the study of fungal infections in this model, which are controlled, to a large extent, by Toll-regulated immune processes. Our work leads us to reconsider our current understanding of the host response to systemic infections by ascribing unexpected functions for several effectors of the Toll pathway, thereby opening novel venues for investigating immune defenses against microbial infections.
-> AI 1153: masks & COVID pass requested
-> Zoom password: Droso
We are interested in the study of fungal infections in this model, which are controlled, to a large extent, by Toll-regulated immune processes. Our work leads us to reconsider our current understanding of the host response to systemic infections by ascribing unexpected functions for several effectors of the Toll pathway, thereby opening novel venues for investigating immune defenses against microbial infections.
-> AI 1153: masks & COVID pass requested
-> Zoom password: Droso
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Organizer
- Bruno Lemaitre