Understanding and reversing fibrosis
Fibrosis is a pathology of excess scarring that occurs across medicine. To understand inflammation and fibrosis, we developed a minimal mathematical model. The model predicts two new kinds of fibrosis, and a key interaction that drives the process. Inhibiting this interaction, an autocrine loop in which scar-forming fibroblasts support their own growth, is predicted to reverse fibrosis. Indeed, inhibiting the autocrine loop reverses fibrosis in mice models of heart attack and liver cirrhosis.
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