Vibrational Photothermal (VIP) Microscopy: A New Window to Watch Life
Event details
| Date | 16.10.2023 |
| Hour | 16:00 › 17:00 |
| Speaker | Prof. Ji-Xin Cheng, Boston University, Boston, MA (USA) |
| Location | |
| Category | Conferences - Seminars |
| Event Language | English |
BIOENGINEERING SEMINAR
Abstract:
Dye-free chemical-bond imaging opens a window for life science and materials science by providing chemical information with minimal perturbation to molecules. Infrared and Raman microscopies are widely used, yet limited by poor spatial resolution or very slow imaging speed. Recently developed coherent anti-Stokes Raman scattering and stimulated Raman scattering microscopy enabled high-speed chemical imaging, whereas their performance is limited by a non-resonant background or a cross phase modulation. Vibrational excitation and subsequent relaxation efficiently generates heat, making photothermal detection a natural and sensitive means of imaging chemical bonds. AFM-IR has allowed nanoscale infrared imaging, but not applicable to live cells. This presentation will introduce a novel optically detected chemical microscopy called vibrational photothermal (VIP) microscopy. Modalities include mid-infrared photothermal (MIP) microscopy and simulated Raman photothermal (SRP) microscopy. Principle, instrumentation, and ground-breaking applications to life science will be discussed.
Bio:
Ji-Xin Cheng, Moustakas Chair Professor in Photonics and Optoelectronics, Professor of Biomedical Engineering, of Electrical & Computer Engineering, of Chemistry and of Physics, attended University of Science and Technology of China (USTC) from 1989 to 1994. From 1994 to 1998, he carried out his PhD study on bond-selective chemistry at USTC. As a graduate student, he worked as a research assistant at Universite Paris-sud (France) on vibrational spectroscopy and the Hong Kong University of Science and Technology (HKUST) on quantum dynamics theory. After postdoctoral training on ultrafast spectroscopy at HKUST, he joined Sunney Xie’s group at Harvard University as a postdoc, where he spearheaded the development of CARS microscopy that allows high-speed vibrational imaging. Cheng joined Purdue University in 2003 as Assistant Professor in Weldon School of Biomedical Engineering and Department of Chemistry, promoted to Associate Professor in 2009 and Full Professor in 2013. He joined Boston University as the Inaugural Theodore Moustakas Chair Professor in Photonics and Optoelectronics in summer 2017. Cheng is authored in 300+ peer-reviewed articles with an h-index of 94 (Google Scholar). Cheng and his team has been constantly at the most forefront of the chemical imaging field in innovation, discovery, and clinical translation. Chemical microscopes based on his innovations, including CARS, hyperspectral SRS, mid-infrared photothermal microscopes, are installed and used in many countries worldwide. His research has been supported by over 40 million ($) funding from federal agencies including NIH, NSF, DoD, DoE and private foundations including Chan-Zuckerburg Initiative and Keck Foundation. In 2014 He co-founded Vibronix Inc which is devoted to vibration-based imaging technologies and medical device innovations. In 2019, he co-founded Pulsethera aiming to kill superbugs by photolysis of intrinsic chromophores. In addition, Cheng is the Scientific Advisor of Photothermal Spectroscopy Corp in Santa Barbara and Axorus in Paris. Cheng is a Fellow of Optical Society of America, a Fellow of American Institute of Medicine and Biological Engineering, and associate editor of Science Advances. Cheng initiated the inaugural Gordon Research Conference on Chemical Imaging, held in Easton, MA in August 2023. Among his honors, Cheng received the 2020 Pittsburgh Spectroscopy Award from the Spectroscopy Society of Pittsburgh, the 2019 Ellis R. Lippincott Award from Optica, Society for Applied Spectroscopy, Coblentz Society, the 2016 Research Award from Purdue University College of Engineering, and the 2015 Craver Award from Coblentz Society. He was chosen as the Boston University Innovator of Year 2022.
Abstract:
Dye-free chemical-bond imaging opens a window for life science and materials science by providing chemical information with minimal perturbation to molecules. Infrared and Raman microscopies are widely used, yet limited by poor spatial resolution or very slow imaging speed. Recently developed coherent anti-Stokes Raman scattering and stimulated Raman scattering microscopy enabled high-speed chemical imaging, whereas their performance is limited by a non-resonant background or a cross phase modulation. Vibrational excitation and subsequent relaxation efficiently generates heat, making photothermal detection a natural and sensitive means of imaging chemical bonds. AFM-IR has allowed nanoscale infrared imaging, but not applicable to live cells. This presentation will introduce a novel optically detected chemical microscopy called vibrational photothermal (VIP) microscopy. Modalities include mid-infrared photothermal (MIP) microscopy and simulated Raman photothermal (SRP) microscopy. Principle, instrumentation, and ground-breaking applications to life science will be discussed.
Bio:
Ji-Xin Cheng, Moustakas Chair Professor in Photonics and Optoelectronics, Professor of Biomedical Engineering, of Electrical & Computer Engineering, of Chemistry and of Physics, attended University of Science and Technology of China (USTC) from 1989 to 1994. From 1994 to 1998, he carried out his PhD study on bond-selective chemistry at USTC. As a graduate student, he worked as a research assistant at Universite Paris-sud (France) on vibrational spectroscopy and the Hong Kong University of Science and Technology (HKUST) on quantum dynamics theory. After postdoctoral training on ultrafast spectroscopy at HKUST, he joined Sunney Xie’s group at Harvard University as a postdoc, where he spearheaded the development of CARS microscopy that allows high-speed vibrational imaging. Cheng joined Purdue University in 2003 as Assistant Professor in Weldon School of Biomedical Engineering and Department of Chemistry, promoted to Associate Professor in 2009 and Full Professor in 2013. He joined Boston University as the Inaugural Theodore Moustakas Chair Professor in Photonics and Optoelectronics in summer 2017. Cheng is authored in 300+ peer-reviewed articles with an h-index of 94 (Google Scholar). Cheng and his team has been constantly at the most forefront of the chemical imaging field in innovation, discovery, and clinical translation. Chemical microscopes based on his innovations, including CARS, hyperspectral SRS, mid-infrared photothermal microscopes, are installed and used in many countries worldwide. His research has been supported by over 40 million ($) funding from federal agencies including NIH, NSF, DoD, DoE and private foundations including Chan-Zuckerburg Initiative and Keck Foundation. In 2014 He co-founded Vibronix Inc which is devoted to vibration-based imaging technologies and medical device innovations. In 2019, he co-founded Pulsethera aiming to kill superbugs by photolysis of intrinsic chromophores. In addition, Cheng is the Scientific Advisor of Photothermal Spectroscopy Corp in Santa Barbara and Axorus in Paris. Cheng is a Fellow of Optical Society of America, a Fellow of American Institute of Medicine and Biological Engineering, and associate editor of Science Advances. Cheng initiated the inaugural Gordon Research Conference on Chemical Imaging, held in Easton, MA in August 2023. Among his honors, Cheng received the 2020 Pittsburgh Spectroscopy Award from the Spectroscopy Society of Pittsburgh, the 2019 Ellis R. Lippincott Award from Optica, Society for Applied Spectroscopy, Coblentz Society, the 2016 Research Award from Purdue University College of Engineering, and the 2015 Craver Award from Coblentz Society. He was chosen as the Boston University Innovator of Year 2022.
Practical information
- Informed public
- Free