ZOOM - ChemBio Seminar by Prof. Chang Liu (University of California, Irvine) – CH-635


Event details

Date 07.11.2023
Hour 16:1517:15
Speaker Prof Chang Liu
Location Online
Category Conferences - Seminars
Event Language English
Experimental evolution of chosen genes near their mutational speed limits

My laboratory engineers genetic systems that go beyond what nature’s genetic systems can do. We are especially interested in creating genetic systems that dramatically accelerate the speed of evolution and that record transient information as interpretable mutations in DNA. We apply these systems to the generation of useful biomolecules and therapeutics; the study of molecular evolution; and cell and developmental biology. I will discuss recent work on our orthogonal DNA replication system for the continuous evolution of biomolecules in vivo, including enzymes and antibodies.

Chang Liu is a Professor and Chancellor's Fellow of Biomedical Engineering, Chemistry, and Molecular Biology & Biochemistry and the Director of the Center for Synthetic Biology at UC Irvine. Liu graduated from Harvard in 2005 with a bachelor’s degree in chemistry and carried out his PhD at the Scripps Research Institute. His PhD work, done in the laboratory of Peter Schultz, focused on expanding bacterial genetic codes for the co-translational incorporation of post-translational modifications and using expanded genetic codes in the evolution of novel protein function. From 2009-2012, Liu was a Miller Fellow at UC Berkeley where he worked with Adam Arkin on the predictable design of complex regulatory systems using the special properties of RNA switches. In 2013, Liu started his lab at UC Irvine. Liu’s research is in the fields of synthetic biology, protein engineering, chemical biology, and directed evolution. His group engineers specialized genetic systems that continuously and rapidly mutate user-selected genes in vivo. These systems allow researchers to evolve proteins at unprecedented speed, scale, and depth in order to engineer new protein functions, probe the rules of evolution, and understand the fundamental sequence-function relationships governing proteins and other macromolecules. These systems also allow researchers to record transient information as heritable mutations in order to track animal and cancer development at high cellular resolution.

Lab website

Practical information

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  • Free