Biophysical Principles of Genome Organization Across Multiple Scales
Event details
| Date | 29.09.2025 |
| Hour | 12:15 › 13:15 |
| Speaker | Prof. Taekjip Ha, Howard Hughes Medical Institute & Program in Cellular and Molecular Medicine, Boston Children's Hospital / Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School |
| Location | |
| Category | Conferences - Seminars |
| Event Language | English |
Recent advances in genetics, biochemistry, cell biology, and biophysics have contributed to our understanding that the genome is organized hierarchically, with higher-order macromolecular assemblies spanning spatial and temporal orders of magnitude. Beyond being wrapped around histones as irregular groups of “beads on a string”, chromatin is organized into topologically associated domains, which are composed of small and large loops, and form euchromatic and heterochromatic compartments. In this talk, I will present biophysical principles we are uncovering about genome organization across three different scales, including sequence-dependent DNA mechanics, chromatin loops for homology search, and polyamines' role in translating nucleosome condensability into 3D genome organization.
Practical information
- General public
- Free
Organizer
- Institut de Physique