Dynamical landscapes of cell fate decisions
Event details
| Date | 14.12.2022 |
| Hour | 15:30 › 16:45 |
| Speaker | Prof. David Rand, University of Warwick, UK |
| Location | |
| Category | Conferences - Seminars |
| Event Language | English |
Abstract. I will discuss an approach to constructing and validating quantitative dynamical models of cellular differentiation inspired by a revised view of developmental landscapes based on past results from catastrophe theory and new results about dynamical systems. The theory suggests a new approach to using single cell expression data to derive quantitative models that can be used to predict. I will describe an application to vertebrate trunk development in which we identify two cell fate decision structures that we believe will be ubiquitous. Collaborators: James Briscoe, Robert Blassberg, Elena Camacho-Aguilar, Francis Corson, Archishman Raju, Meritxell Saez, Eric Siggia.
David started his career as a mathematician making landmark contributions notably in dynamical systems. In the last years he has made a number of impressive contributions to systems and quantitative biology, notably on biological oscillators and developmental systems. Notably his recent work on using geometrical principles to reconstruct potential landscape models for developmental systems should interest many of you:
https://doi.org/10.1016/j.cels.2021.08.013
His publications are listed here:
https://www.davidrand.uk/page2/index.html
Professor David Rand is Professor of Mathematics at the Mathematics Institute & Zeeman Institute for Systems Biology and Infectious Epidemiology Research, University of Warwick, UK
David started his career as a mathematician making landmark contributions notably in dynamical systems. In the last years he has made a number of impressive contributions to systems and quantitative biology, notably on biological oscillators and developmental systems. Notably his recent work on using geometrical principles to reconstruct potential landscape models for developmental systems should interest many of you:
https://doi.org/10.1016/j.cels.2021.08.013
His publications are listed here:
https://www.davidrand.uk/page2/index.html
Professor David Rand is Professor of Mathematics at the Mathematics Institute & Zeeman Institute for Systems Biology and Infectious Epidemiology Research, University of Warwick, UK
Practical information
- Informed public
- Free