Evolution of the outer mitochondrial membrane
|12:15 › 13:15
|Lena Pernas, Dept. of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, USA / Metabolism of Infection Group, Max Planck Institute for Biology of Ageing, Cologne, Germany / HHMI Freeman Hrabowski Scholar
|Conferences - Seminars
The rewiring of mitochondrial metabolism serves as an innate immune-type defense mechanism that restricts the growth of the human parasite Toxoplasma gondii. We recently reported a previously undescribed structure we term SPOT (structure positive for outer mitochondrial membrane (OMM) that emerges from the OMM during infection. We propose that Toxoplasma hijacks the formation of SPOTs, a cellular response to OMM import stress, to promote its growth. Here, I discuss the fate and function of these peculiar structures.