Evolution of the outer mitochondrial membrane


Event details

Date 05.12.2023
Hour 12:1513:15
Speaker Lena Pernas, Dept. of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, USA / Metabolism of Infection Group, Max Planck Institute for Biology of Ageing, Cologne, Germany / HHMI Freeman Hrabowski Scholar                                                                                                       
Category Conferences - Seminars
Event Language English

The rewiring of mitochondrial metabolism serves as an innate immune-type defense mechanism that restricts the growth of the human parasite Toxoplasma gondii. We recently reported a previously undescribed structure we term SPOT (structure positive for outer mitochondrial membrane (OMM) that emerges from the OMM during infection. We propose that Toxoplasma hijacks the formation of SPOTs, a cellular response to OMM import stress, to promote its growth. Here, I discuss the fate and function of these peculiar structures.

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  • Andrea Ablasser