Taking Apart the Nuclear Envelope for Open Mitosis
|Date and time||06.07.2021 – 12:15 › 13:15|
|Speaker||Ulrike Kutay, Institute of Biochemistry, ETHZ|
|Category||Conferences - Seminars|
Entry into mitosis is accompanied by drastic alterations in cellular organization to prepare cells for division. The complete disintegration of the nuclear compartment is a hallmark of open mitosis in higher eukaryotes and well suited to uncover the principles governing the rapid reorganization of cells during prophase. In my talk, I will touch upon two main aspects of nuclear envelope reorganization during mitotic entry of human cells. Firstly, I will summarize our work on deciphering the molecular mechanisms that govern the mitotic disassembly of nuclear pore complexes. Secondly, I will present our recent work on the dissolution of NE–chromatin contacts, which revealed an unexpected role of Torsin AAA+-ATPases in modulating chromatin contacts established by the inner nuclear membrane protein LAP1.