Taking Apart the Nuclear Envelope for Open Mitosis


Event details

Date and time 06.07.2021 12:1513:15  
Online https://epfl.zoom.us/meeting/register/tJAkfuyoqzsqEtxFujqV5KheYMCUrcg31IiS
Speaker Ulrike Kutay, Institute of Biochemistry, ETHZ
Category Conferences - Seminars

Entry into mitosis is accompanied by drastic alterations in cellular organization to prepare cells for division. The complete disintegration of the nuclear compartment is a hallmark of open mitosis in higher eukaryotes and well suited to uncover the principles governing the rapid reorganization of cells during prophase. In my talk, I will touch upon two main aspects of nuclear envelope reorganization during mitotic entry of human cells. Firstly, I will summarize our work on deciphering the molecular mechanisms that govern the mitotic disassembly of nuclear pore complexes. Secondly, I will present our recent work on the dissolution of NE–chromatin contacts, which revealed an unexpected role of Torsin AAA+-ATPases in modulating chromatin contacts established by the inner nuclear membrane protein LAP1.

Practical information

  • Informed public
  • Free


  • Andrea Ablasser