Taking Apart the Nuclear Envelope for Open Mitosis
Entry into mitosis is accompanied by drastic alterations in cellular organization to prepare cells for division. The complete disintegration of the nuclear compartment is a hallmark of open mitosis in higher eukaryotes and well suited to uncover the principles governing the rapid reorganization of cells during prophase. In my talk, I will touch upon two main aspects of nuclear envelope reorganization during mitotic entry of human cells. Firstly, I will summarize our work on deciphering the molecular mechanisms that govern the mitotic disassembly of nuclear pore complexes. Secondly, I will present our recent work on the dissolution of NE–chromatin contacts, which revealed an unexpected role of Torsin AAA+-ATPases in modulating chromatin contacts established by the inner nuclear membrane protein LAP1.